(R)-1-Boc-3-Aminopiperidine synthesis
- Product Name:(R)-1-Boc-3-Aminopiperidine
- CAS Number:188111-79-7
- Molecular formula:C10H20N2O2
- Molecular Weight:200.28
![1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-](/CAS/GIF/320580-76-5.gif)
320580-76-5
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188111-79-7
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Yield:188111-79-7 99%
Reaction Conditions:
Pd-C in methanol
Steps:
22 Synthesis of 3(R)-amino-piperidine-1-carboxylic Acid Tert-Butyl Ester
EXAMPLE 22 Synthesis of 3(R)-amino-piperidine-1-carboxylic Acid Tert-Butyl Ester To a slurry of Pd-C 10%, 170 mg) in MeOH (2 ml) was added a solution of the 3(R)-Benzyloxycarbonylamino-piperidine-1-carboxylic acid tert-butyl ester (1.0 g) in MeOH (60 ml). The mixture was stirred under H2 (1 atm) for 8 hr. After being filtered through Celite, the filtrate was evaporated to give a light yellow oil (572 mg, 99%). 1H-NMR (300 MHz, CDCl3) δ 4.00-3.78 (m, 2H), 3.80 (m, 2H), 3.60 (m, 1H), 1.90 (m, 1H), 1.70 (m, 1H), 1.60-1.40 (m, 12H), 1.30 (m, 1H) ppm; IR (film) 3485, 3361, 3292, 2975, 22931, 2862, 1692, 1608, 1548, 1479, 1427, 1367, 1266, 1242, 1162 cm-1; LRMS (calculated for C10,H20N2O2) 200, found 200.
References:
Aquila, Brian M.;Cuny, Gregory D.;Hauske, James R.;Shao, Liming;Wu, Xinhe US2001/56090, 2001, A1
98977-36-7
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188111-79-7
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915226-43-6
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188111-79-7
358 suppliers
$6.00/1g