Phenetole synthesis
- Product Name:Phenetole
- CAS Number:103-73-1
- Molecular formula:C8H10O
- Molecular Weight:122.16
Yield:103-73-1 96.1%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide;toluene at 40 - 50; for 2.25 h;Large scale;Time;
Steps:
1.1; 2.1 Step 1) Preparation of phenethyl ether
Phenol (14.1 g, 150 mmol) was dissolved in 300 ml DMF,Add 25g of potassium carbonate, at room temperature,Add dropwise a solution of bromoethane in toluene (15ml of bromoethane, 60ml of toluene),After 15 minutes of dripping, the dripping was completed, and the reaction was performed at 40-50 °C for 2 hours.After the reaction was finished, potassium bromide and potassium carbonate were removed by filtration, and the solvent was recovered under reduced pressure,The residue was added with 250ml of water, extracted with 250ml of ethyl acetate,Dry over anhydrous sodium sulfate, filter, and recover the solvent from the filtrate,The residue was distilled under reduced pressure to obtain 17.58 kg of a light-colored liquid with a yield of 96.1%.
References:
CN114315534,2022,A Location in patent:Paragraph 0016; 0034-0036; 0041-0043
105-58-8
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$15.00/25g
108-95-2
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103-73-1
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$8.00/25g
