N-Methyl pyrrole synthesis
- Product Name:N-Methyl pyrrole
- CAS Number:96-54-8
- Molecular formula:C5H7N
- Molecular Weight:81.12
Yield:96-54-8 93%
Reaction Conditions:
with sodium hydroxide in dimethyl sulfoxide at 20; for 5 h;
Steps:
2.1 The synthesis method of (1) is as follows:
Take pyrrole (10mmol), methyl iodide (11mmol),Sodium hydroxide (11 mmol) was added to 20 mL of dimethyl sulfoxide.Stirring at room temperature for 5 hours to obtain a reaction liquid;Adding a saturated aqueous solution of sodium chloride to the reaction solution,Extracted with ethyl acetate, the organic phase is concentrated and purified by column.The collected purification liquid was distilled under reduced pressure to give 753 mg (9.3 mmol) of N-methylpyrrole in a yield of 93%.
References:
Wang Xiaozhou;Yang Rong;Wang Qingfeng CN109535126, 2019, A Location in patent:Paragraph 0046; 0047-0048
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![1H-Pyrrole, 2,3-bis[(1,1-dimethylethyl)thio]-1-methyl-](/CAS/20210305/GIF/62317-64-0.gif)
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