1-Methylimidazole synthesis
- Product Name:1-Methylimidazole
- CAS Number:616-47-7
- Molecular formula:C4H6N2
- Molecular Weight:82.1
(CHO)2 + CH2O + CH3NH2 + NH3 → H2C2N(NCH3)CH + 3 H2O
The compound can be synthesized on a laboratory scale by methylation of imidazole at the pyridine-like nitrogen and subsequent deprotonation. Similarly, 1-methylimidazole may be synthesized by first deprotonating imidazole to form a sodium salt followed by methylation.
H2C2N(NH)CH + CH3I → [H2C2(NH)(NCH3)CH]I
[H2C2(NH)(NCH3)CH]I + NaOH → H2C2N(NCH3)CH + H2O + NaI
35487-17-3
52 suppliers
$56.00/25g
616-47-7
742 suppliers
$10.00/100g
Yield:616-47-7 98.5%
Reaction Conditions:
with sodium methylate
Steps:
36
Lower layer separated in Example 1 was added with 20.84 g (0.521 moles) of sodium hydroxide at room temperature, followed by stirring for 1 hour. 1- Methylimidazole was recovered (recovery 97.6%) by distilling the remaining solution at a reduced pressure after the produced NaCl was filtered; 1-Methy limidazole was recovered by following the same procedure as described in Example 31 except by using sodium methoxide (NaOCHs) instead of sodium hydroxide, and the recovery was 98.5%.
References:
WO2008/1985,2008,A1 Location in patent:Page/Page column 11
131543-46-9
0 suppliers
inquiry
75-07-0
423 suppliers
$14.00/5mL
74-89-5
0 suppliers
$13.44/25ML
616-47-7
742 suppliers
$10.00/100g
1739-84-0
414 suppliers
$6.00/25g
693-98-1
733 suppliers
$10.00/25g
288-32-4
1026 suppliers
$5.00/25g
74-87-3
212 suppliers
$18.50/48622
616-47-7
742 suppliers
$10.00/100g
288-32-4
1026 suppliers
$5.00/25g
24100-18-3
251 suppliers
$6.00/1g
616-47-7
742 suppliers
$10.00/100g