IODOPENTAFLUOROBENZENE synthesis

5synthesis methods

Product Name:IODOPENTAFLUOROBENZENE
CAS Number:827-15-6
Molecular formula:C6F5I
Molecular Weight:293.96

363-72-4
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$10.00/1 g

827-15-6
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$34.00/5g

Yield:827-15-6 99%

Reaction Conditions:

with 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane;sodium t-butanolate in N,N-dimethyl-formamide at 20; for 0.166667 h;

Steps:

5 Example 5 Synthesis of pentafluoroiodobenzene
Compound pentafluorobenzene (1 mmol, 168.1 mg)Perfluoroiodobutane (1.1 mmol, 380.5 mg) was placed in a 10 mL round-bottomed flask that was coated with tin foil.Added 5 mL of N,N-dimethylformamide and sodium tert-butoxide (0.5 mmol, 48.1 mg).Stir at room temperature for 10 minutes,TLC monitored the endpoint of the reaction.The mixture was poured into water and extracted with dichloromethane. The organic phase was collected and dried. The dichloromethane was removed by rotary evaporation at low temperature to obtain a crude product.The crude product was passed through silica gel column chromatography and petroleum ether as eluent.Pentafluoroiodobenzene (colorless liquid, 291 mg, yield 99%) was obtained.

References:

Liaoning University;Liang Fushun;Liu Xia;Han Zhengbo;Su Zhongmin CN107501023, 2017, A Location in patent:Paragraph 0041; 0042

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