ChemicalBook CAS DataBase List 1,2,4-Trifluorobenzene

1,2,4-Trifluorobenzene synthesis

12synthesis methods

Product Name:1,2,4-Trifluorobenzene
CAS Number:367-23-7
Molecular formula:C6H3F3
Molecular Weight:132.08

446-17-3 Synthesis

446-17-3
400 suppliers
$6.00/5g

367-23-7
373 suppliers
$8.00/5g

Yield:367-23-7 94.9%

Reaction Conditions:

with ammonia;copper in water at 260; for 1.25 h;Temperature;Reagent/catalyst;

Steps:

11
In the 500mL intermittent high pressure reaction kettle 300 g aqueous ammonia solution with ammonia concentration of 2 g / L, 60. 0g 2, 4, 5-trifluorobenzoic acid and 2. 00g copper powder, stir, The temperature was raised to 260 ° C decarboxylation reaction for 1.25 h. After decarboxylation reaction was completed, Open the exhaust valve pressure relief, recovery of ammonia inside the kettle; cooling to room temperature, The catalyst was recovered by filtration, and the filtrate was allowed to stand under the liquid-liquid layer to obtain the organic phase and the aqueous phase. After the organic phase was distilled, 1,2,4-trifluorobenzene 42. 7 g, The product was analyzed by HPLC for purity 98.9%, the yield was 94.9%.

References:

Zhejiang Chemical Industry Institute Technology Co., Ltd;Zhejiang University;Fu, Jie;Mo, Jing;Lyu, Xiuyang;XU, Weiguo CN105732302, 2016, A Location in patent:Paragraph 0039; 0040

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165047-24-5 Synthesis