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ChemicalBook CAS DataBase List HEXANAMIDE
628-02-4

HEXANAMIDE synthesis

14synthesis methods
-

Yield:628-02-4 78%

Reaction Conditions:

with ammonia;oxygen;copper in chlorobenzene;acetonitrile at 100;Sealed tube;

Steps:

15 Synthesis Example 15 Synthesis of n-hexanamide
50 mol% Cu was added to the reaction vessel, the reaction tube was evacuated and filled with oxygen, and 0.2 mmol of n-heptanitrile, 0.5 mmol of ammonia, 1 ml of acetonitrile and 1 ml of chlorobenzene were added in an oxygen atmosphere, the reaction vessel was sealed, and reacted at 100 ° C,After completion of the reaction, it was washed with water, extracted with chloroform, dried and evaporated to remove the solvent by distillation under reduced pressure. The crude product was separated by column chromatography to give the desired product in a yield of 78%.

References:

Hubei College Of Sciences And Technology;Chen Xiuling CN106478442, 2017, A Location in patent:Paragraph 0070; 0071; 0072

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