Ethyl 4-methylbenzoate synthesis
- Product Name:Ethyl 4-methylbenzoate
- CAS Number:94-08-6
- Molecular formula:C10H12O2
- Molecular Weight:164.2
Yield:94-08-6 99%
Reaction Conditions:
with oxone at 65; for 30 h;
Steps:
4.3 General procedure for preparation of esters (RCO2R′) 5 from 2-oxoacids (RCOCO2H) 3/2-oxoaldehydes (RCOCHO) 3 &/2-oxoesters (RCOCO2R″) 4
General procedure: A mixture of 2-oxoacids 2/2-oxoaldehydes 3/2-oxoesters 4 (0.5mmol), oxone (1.25mmol) and alcohol (1.5mL) in round bottomed flask was stirred at 65°C. After completion of the reaction that was confirmed by thin layer chromatography, the crude mixture was cooled to room temperature, filtered and purified by column chromatography using silica gel (100-200 ) with ethyl acetate and hexane as an eluent to afford the desired product 5 in 70-99 % yields.
References:
Padala, Anil K.;Saikam, Varma;Ali, Asif;Ahmed, Qazi Naveed [Tetrahedron,2015,vol. 71,# 50,p. 9388 - 9395] Location in patent:supporting information
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