Coumaphos synthesis
1synthesis methods
- Product Name:Coumaphos
- CAS Number:56-72-4
- Molecular formula:C14H16ClO5PS
- Molecular Weight:362.77
Yield:56-72-4 58%
Reaction Conditions:
Stage #1:3-chloro-4-methylumbelliferone with n-butyllithium in tetrahydrofuran;hexane for 1 h;
Stage #2:diethyl phosphorochloridothioate in tetrahydrofuran;hexane at 20; for 12 h;
References:
Briseno-Roa, Luis;Hill, Jim;Notman, Stuart;Sellers, David;Smith, Andy P.;Timperley, Christopher M.;Wetherell, Janet;Williams, Nichola H.;Williams, Gareth R.;Fersht, Alan R.;Griffiths, Andrew D. [Journal of Medicinal Chemistry,2006,vol. 49,# 1,p. 246 - 255]