Clomipramine synthesis
- Product Name:Clomipramine
- CAS Number:303-49-1
- Molecular formula:C19H23ClN2
- Molecular Weight:314.85
![5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine](/CAS/GIF/25961-11-9.gif)
25961-11-9
161 suppliers
$8.00/1g
303-49-1
116 suppliers
$189.52/250mg
Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: potassium hydroxide; triethyl borane / tetrahydrofuran / 24 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube
2.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube
3.1: sodium hydride / tetrahydrofuran / 2 h / 110 °C / Glovebox; Inert atmosphere; Schlenk technique
3.2: 22 h / 110 °C / Glovebox; Inert atmosphere; Schlenk technique
References:
Li, Jinshan;Wang, Jiali;Yang, Jianguo;Yao, Wubing;Zhong, Aiguo [Organic Letters,2020,vol. 22,# 20,p. 8086 - 8090]
![3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepine](/CAS/GIF/32943-25-2.gif)
32943-25-2
246 suppliers
$10.00/1g
53929-74-1
50 suppliers
inquiry
303-49-1
116 suppliers
$189.52/250mg
14171-67-6
27 suppliers
$80.00/1mg
303-49-1
116 suppliers
$189.52/250mg
106-39-8
449 suppliers
$14.00/5g
303-49-1
116 suppliers
$189.52/250mg
615-36-1
413 suppliers
$10.00/5g
303-49-1
116 suppliers
$189.52/250mg