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ChemicalBook CAS DataBase List Dimethyl phthalate
131-11-3

Dimethyl phthalate synthesis

14synthesis methods
Dimethyl phthalate is produced industrially from phthalic anhydride and methanol.
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Yield:131-11-3 96%

Reaction Conditions:

with sulfuric acid for 24 h;Reflux;

Steps:

Synthesis of phthalic acid ester 3

Phthalic acid (2, 6.00 g, 36.2 mol) was dissolved in methanol (130 mL). After thatconc. sulfuric acid (6.80 mL) was slowly added dropwise. The reaction mixture wasstirred under reflux for 24 h. After cooling down to room temperature the solution wasconcentrated and added to a mixture of 200 mL dichloromethane/water (1:1). Theaqueous phase was extracted three times with dichloromethane. The combinedorganic layers were dried over magnesium sulfate and the solvent was removedunder reduced pressure. A yellow oil was obtained

References:

Peters, Morten K.;Herges, Rainer [Beilstein Journal of Organic Chemistry,2017,vol. 13,p. 2659 - 2662] Location in patent:supporting information

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