BOC-L-4-Nitrophe synthesis
- Product Name:BOC-L-4-Nitrophe
- CAS Number:33305-77-0
- Molecular formula:C14H18N2O6
- Molecular Weight:310.3
24424-99-5
833 suppliers
$13.50/25G
949-99-5
360 suppliers
$11.00/1g
33305-77-0
262 suppliers
$6.00/5g
Yield:33305-77-0 88%
Reaction Conditions:
in tetrahydrofuran;sodium hydroxide
Steps:
48.A (S)-N-boc-4-nitrophenylalanine
Example 48A (S)-N-boc-4-nitrophenylalanine To a solution of (S)-4-nitrophenylalanine (2.00 g, 9.51 mmol) in aqueous 2M NaOH (10 mL) and THF (5 mL), was added di-tertbutyldicarbonate (2.00 g, 9.17 mmol) in THF (5 mL). The reaction was stirred at ambient temperature for 1 hour, diluted with H2O (25 mL) and 1M HCl (25 mL), extracted with ether (3*25 mL). The combined ether layers were extracted with brine (1*25 mL), dried (MgSO4), filtered, and concentrated under reduced pressure to provide the titled compound (2.51 g, 88%).
References:
Liu, Gang;Szczepankiewicz, Bruce G.;Pei, Zhonghua;Xin, Zhili;Oost, Thorsten K.;Janowick, David A. US2002/35137, 2002, A1
65615-89-6
48 suppliers
$120.00/250mg
33305-77-0
262 suppliers
$6.00/5g
74-96-4
441 suppliers
$9.00/5g
24424-99-5
833 suppliers
$13.50/25G
949-99-5
360 suppliers
$11.00/1g
33305-77-0
262 suppliers
$6.00/5g
