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ChemicalBook CAS DataBase List Bisoctrizole
103597-45-1

Bisoctrizole synthesis

2synthesis methods
-

Yield:103597-45-1 96.3%

Reaction Conditions:

Stage #1: formaldehyd;Cyasorb UV 5411with diethylamine in 1,3,5-trimethyl-benzene at 130; for 4 h;
Stage #2: with sodium methylate in 1,3,5-trimethyl-benzene at 160; for 5 h;Temperature;Solvent;Reagent/catalyst;

Steps:

4 Example 4

Equipped with a stirring thermometer,Condenser of 500 ml four-necked flask,Adding mesitylene 67ml,UV-329108.0 g, diethylamine 36.6 g, paraformaldehydeAnd the temperature was gradually raised to 130 ° C,Keeping for 4 hours while distilling diethylamine and water;Then 5.4 g of sodium methoxide was added,Slowly raised to 160 ° C,The reaction was incubated for 5 hours while removing diethylamine and water,Then cooled to 110 ° C,Adding formic acid to pH 5-6,Stirred for 30 minutes,100 ml of methanol was added,Heating reflux,And then cooled to 20-25 ,Heat 60 minutes,Filtration, drying the filter cake to obtain UV-360106.0g, yield 96.3% (UV-329 dollars), liquid chromatography analysis of the content of 99.56%.

References:

CN105566238,2016,A Location in patent:Paragraph 0027; 0028

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