2,4-Dihydroxybenzophenone synthesis
- Product Name:2,4-Dihydroxybenzophenone
- CAS Number:131-56-6
- Molecular formula:C13H10O3
- Molecular Weight:214.22
Yield:131-56-6 99%
Reaction Conditions:
with ethanol;water at 60 - 80; for 9 h;Green chemistry;Temperature;
Steps:
1; 2; 3 Example 3
(1) 660.6g 2% ethanol-water solution and 110.18 (1.0 mol) of resorcinol recovered after one reaction were added to a 2000 mL four-neck glass reaction flask equipped with a stirrer, a thermometer, a dropping funnel and a condenser , start stirring, the system heated to 60 °C, slowly adding 254.1g (1.3mol) trichloromethylbenzenein 1h, after the drop, at 80 °C conditions continue to heat the reaction for 8h. (2) After completion of the reaction, the system temperature was cooled to 25 °C at a cooling rate of 30 °C / h, vacuum filtration, and the filter cake was a crude product of 2,4-dihydroxybenzophenone, : Crude product quality = 5: 1 dissolved crude product, at 2 °C under the recrystallization, vacuum filtration, filter cake at -0.1MPa, 60 °C dry 12h, pale yellow needle-like crystals 2,4-dihydroxybenzophenone 212.1 g, yield 99%, purity 95%, isomer impurity 4%.
References:
CN106083543,2016,A Location in patent:Paragraph 0033; 0065-0086
65-85-0
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131-56-6
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