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ChemicalBook CAS DataBase List 8-BROMO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE
651735-60-3

8-BROMO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE synthesis

10synthesis methods
-

Yield: 95%

Reaction Conditions:

with pyridinium chlorochromate in dichloromethane

Steps:

22 Intermediate 8-bromo-3,4-dihydronaphthalen-1(2H)-one
Pyridinium chlorochromate (PCC) (64.29 mmol) was added to a stirring solution of 8-bromo-1,2,3,4-tetrahydronaphthalen-1-ol (12.86 mmol) in dichloromethane (150 mL). The reaction mixture was passed through a silica plug and solvent was removed in vacuo. Yield: 2.76 g (95%)

References:

ExxonMobil Chemical Patents Inc.;Samsonov, Oleg V.;Sharikov, Mikhail I.;Goryunov, Georgy P.;Uborsky, Dmitry Dmitry;Voskoboynikov, Alexander Z.;Titone, Michelle E.;Hagadorn, John R.;Canich, Jo Ann M. US2020/71344, 2020, A1 Location in patent:Paragraph 0295-0296

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