ChemicalBook CAS DataBase List 2-(3-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

2-(3-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER synthesis

4synthesis methods

Product Name:2-(3-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
CAS Number:786654-97-5
Molecular formula:C12H10BrNO2S
Molecular Weight:312.18

2227-62-5 Synthesis

2227-62-5
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$11.00/1g

70-23-5
310 suppliers
$6.00/5g

2-(3-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

786654-97-5
49 suppliers
$75.00/1g

Yield:786654-97-5 79%

Reaction Conditions:

in ethanol; for 16 h;Heating / reflux;

Steps:

1.a

Example 1; 2-tert-butoxycarbonylamino-3- [2- (3-dibenzofuran-4-yl-phenyl) - thiazol-4-ylmethylsulfanyl] -propionic acid; Preparation of 2- (3-bromo-phenyl) -thiazole-4-carboxylic acid ethyl ester; A solution of 3-bromo-thiobenzamide (6.4 g, 29.6 mmol) and 3-bromo-2-oxo-propionic acid ethyl ester (6.4 g, 33.1 mmol) in ethanol (50 mL, 0.6 M) is refluxed for 16 hours. After evaporation of the solvent, the residue is purified by flash chromatography (15% ethyl acetate in heptane) to give 2-(3-bromo-phenyl) -thiazole-4-carboxylic acid ethyl ester (7.3 g, 79%) as a white solid. ¹H NMR (CDCl₃, 300 MHz) δ 8.18-8.16(m, 2 H), 7.89 (dd, J₁ = 1.8 Hz, J₂ = 1.0 Hz, 1 H) , 7.56 (dd, J₁ = 1.8 Hz, J₂ = 1.0 Hz, 1 H), 7.31 (t, J = 7.9 Hz, 1 H), 4.44(q, J = 7.2 Hz, 2 H), 1.43 (t, J = 7.2 Hz, 3 H).

References:

WO2008/33934,2008,A1 Location in patent:Page/Page column 85

100367-77-9 Synthesis