ChemicalBook CAS DataBase List 5-BroMobenzothiophene-2-carboxylic Acid Methyl Ester

5-BroMobenzothiophene-2-carboxylic Acid Methyl Ester synthesis

3synthesis methods

Product Name:5-BroMobenzothiophene-2-carboxylic Acid Methyl Ester
CAS Number:7312-11-0
Molecular formula:C10H7BrO2S
Molecular Weight:271.13

149947-15-9 Synthesis

149947-15-9
160 suppliers
$6.00/1g

2365-48-2 Synthesis

2365-48-2
348 suppliers
$14.00/25g

5-BroMobenzothiophene-2-carboxylic Acid Methyl Ester

7312-11-0
93 suppliers
$25.00/100mg

Yield:7312-11-0 97.7%

Reaction Conditions:

with pyridine in (methylsulfinyl)methane at 60 - 120;Inert atmosphere;

Steps:

5 Example 5:

To the 1000ML reactor, add 3-bromo-2-fluorobenzaldehyde (30.0g, 0.15mol), dissolve in 300ml dimethyl sulfoxide, add pyridine (33.3g, 0.45mol), and then dropwise add thioglycolic acid Methyl ester (15.9g, 0.15mol) was heated to 60°C-120°C under nitrogen protection, heated for 1-5 hours, cooled to room temperature after the reaction was completed, extracted with ethyl acetate and water, and the organic phase was dried with suction filtration, The obtained filtrate was concentrated under reduced pressure to obtain the intermediate S9,5-bromobenzothiophene-2-carboxylic acid methyl ester, 39.7 g, HPLC=96.2, yield 97.7%.

References:

CN114907335,2022,A Location in patent:Paragraph 0070-0072

2365-48-2 Synthesis

2365-48-2
348 suppliers
$14.00/25g

93777-26-5 Synthesis