ChemicalBook CAS DataBase List (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone

(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone synthesis

10synthesis methods

Product Name:(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone
CAS Number:1103738-26-6
Molecular formula:C15H12ClIO2
Molecular Weight:386.61

915095-86-2 Synthesis

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

915095-86-2
225 suppliers
$5.00/250mg

141-52-6 Synthesis

141-52-6
470 suppliers
$10.00/5g

(2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone

1103738-26-6
122 suppliers
$18.00/100mg

Yield: 86.5%

Reaction Conditions:

in N,N-dimethyl-formamide at 20; for 1.5 h;Cooling with ice;Solvent;Temperature;

Steps:

3 Example 3 Preparation of (5-iodo-2-chlorophenyl) (4-ethoxyphenyl) methanone (Compound IIb)
5-iodo-2-chlorophenyl) (4-fluorophenyl) methanone (18.03 g, 50 mmo 1) was added DMF (90 mL), Ice bath slowly add sodium ethoxide (3.748,1. Eq), After adding the reaction at room temperature for 1.5 h, tlc (after the detection reaction is completed, Ice bath slowly add water (180mL), Stirring crystallization lh, Filter, The filter cake was washed with water (200 mL) Beat with ethanol (50 mL) Filtered and dried to give 16.72 g of the pale yellow solid of compound lib, Yield: 86.5% Purity: 99.53%.

References:

Shanghai Pharmaceutical Industry Institute;China Pharmaceutical Industry Zongyuan;Ma Shuai;Zhou Weicheng CN106928040, 2017, A Location in patent:Paragraph 0042-0047