4-[2-(Dimethylamino)ethyl]morpholine synthesis
- Product Name:4-[2-(Dimethylamino)ethyl]morpholine
- CAS Number:4385-05-1
- Molecular formula:C8H18N2O
- Molecular Weight:158.24
Yield:4385-05-1 81%
Reaction Conditions:
with sodium carbonate in tetrahydrofuran at 70; for 8 h;Solvent;Reagent/catalyst;Temperature;
Steps:
1-4 Preparation of 4-(2-(N,N-dimethylamino)ethyl)morpholine
At room temperature, add N, N-dimethylethylenediamine (0.528g, 6.0 ol), tetrahydrofuran (30mL) solution, sodium carbonate (0.636g, 6.0mmol) to a 100ml round bottom flask in sequence , While stirring, add dropwise 2,2'-diethylene glycol sulfonate (0.760g, 5.0mmol) in tetrahydrofuran (20mL)The solution, in which the molar ratio of 2,2'-diethylene glycol sulfonate, N,N-dimethylethylenediamine, and sodium carbonate is 1:1.2:1.2; after the addition is completed, slowly increase the temperature to 70 °C, react for 8h (TLC to track the progress of the reaction); after the completion of the reaction, evaporate the solvent, add purified water (50ml) and extract with dichloromethane (20ml*3), separate the layers, dry the organic phase with anhydrous sodium sulfate, and concentrate The crude product was obtained and purified by column chromatography to obtain 0.640 g of pure product with a yield of 81.0%.
References:
CN112209901,2021,A Location in patent:Paragraph 0030-0054
3240-94-6
121 suppliers
$27.00/1g
124-40-3
518 suppliers
$18.00/100ml
4385-05-1
74 suppliers
inquiry