ChemicalBook CAS DataBase List 4-(2-Chloroethyl)morpholine

4-(2-Chloroethyl)morpholine synthesis

6synthesis methods

Product Name:4-(2-Chloroethyl)morpholine
CAS Number:3240-94-6
Molecular formula:C6H12ClNO
Molecular Weight:149.62

622-40-2 Synthesis

622-40-2
334 suppliers
$5.00/25g

3240-94-6
118 suppliers
$27.00/1g

Yield:3240-94-6 74%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in dichloromethane at 0 - 40;

Steps:

2.2 Synthesis of 4-(2-chloroethyl)morpholine
To a stirred solution of 2-morpholinoethan-l-ol (step 1, 2.5 g, 13.88 mmol, 1.0 eq) in DCM (25 ml) at 0 °C then added thionyl chloride (5.06 mL, 69.44 mmol, 5.0 eq) followed by DMF (Cat.). The reaction mixture was heated to 40 °C for overnight. After completion of the reaction (monitored by TLC), the solvent was evaporated in vacuo providing a crude residue, which was diluted with DCM and washed with saturated sodium bicarbonate solution. Organic layer was concentrated under reduced preesure gave crude residue which was purified by column chromatography by using 3% MeOH in DCM as an eluent to afford the desired compound (2.0 g, yield: 74.0%) as a colour less liquid. 1H NMR (DMSO-d₆, 300MHz): δ 3.69 (t, J = 6.9 Hz, 2H), 3.57 (m, J = 4.5 Hz, 4H), 2.64 (t, J = 6.9 Hz, 2H) and 2.43 (t, J = 4.5 Hz, 4H); Mass: [M+H]⁺149.95 (10%).

References:

HETERO LABS LIMITED;BANDI, Parthasaradhi Reddy;KURA, Rathnakar Reddy;GAZULA LEVI, David Krupadanam;ADULLA, Panduranga Reddy;MUKKERA, Venkati;NEELA, Sudhakar WO2017/149518, 2017, A1 Location in patent:Page/Page column 25; 26

FullText

3647-69-6 Synthesis