ChemicalBook CAS DataBase List 3-Methylthiophene

3-Methylthiophene synthesis

8synthesis methods

Product Name:3-Methylthiophene
CAS Number:616-44-4
Molecular formula:C5H6S
Molecular Weight:98.17

17249-90-0
133 suppliers
$35.00/25g

616-44-4
244 suppliers
$18.00/25g

Yield:616-44-4 95.33%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen;potassium hydroxide in methanol at 80; under 60006 Torr; for 24 h;

Steps:

4.2 4.2 Preparation of 3-methylthiophene
167.06 g (1 mol) of 2,5-dichloro-3-methylthiophene, 13 g (12.22 mmol) of 10% Pd / C, 1000 mL of methanol, and 56 g (1 mol) of potassium hydroxide were added to 2 L of In an autoclave, after replacing the hydrogen 3 times, the hydrogen pressure was adjusted to 8 MPa, and the reaction was heated to 80 ° C. for 24 hours. After naturally cooling to room temperature, the catalyst and insoluble matter were filtered off, and atmospheric pressure distillation was used to obtain 93.58 g of 2-methylthiophene The yield was 95.33%, and the purity of the product was 99.75% by GC;

References:

Henan Chemical Institute Co., Ltd.;Huo Erfu;Wang Yinan;Cheng Weiqin;Feng Ming;Wang Yanhua;Wang Bonan;Shao Guobin;Shi Chuanxing;Yang Xianhong;Zhao Yili;Gu Zhongming;Wu Zhen;Kuang Wenhui;Xing Wenting;Zhang Qianhua;Zhang Chunling;Han Juan;Du Yujie;Liu Xiuwei CN110498763, 2019, A Location in patent:Paragraph 0052; 0056; 0057; 0058

FullText

71637-34-8 Synthesis