3-Thiophenemalonic acid synthesis
- Product Name:3-Thiophenemalonic acid
- CAS Number:21080-92-2
- Molecular formula:C7H6O4S
- Molecular Weight:186.19
81344-59-4
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21080-92-2
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Yield:21080-92-2 79.6%
Reaction Conditions:
with water;sodium hydroxide at 25 - 30;
Steps:
2.3 Example 2
(3) 22g of sodium hydroxide is added to 120g of water, cooled to 25°C, and the prepared sodium hydroxide solution is added to33.2 g of the yellow oily liquid B obtained in step (2) is reacted at 25 to 30° C. for 1 to 2 hours, and 12.8 g of concentrated hydrochloric acid is used after the reaction is completed.The pH of the reaction solution was adjusted to 2, and the aqueous phase was extracted with methylene chloride for 3 to 4 times. The resulting organic phase was concentrated under reduced pressure at 45° C. to a solid state.Out, cooled to -5 ~ 0 °C decrystallized 2 ~ 3h, and then filtered to obtain the intermediate ticarcillin sodium 2- (3-thienyl) malonic acid32.2 g, drying to dryness under reduced pressure at 45° C., dry weight 29.4 g, content 98.7%, molar yield 79.6% (with tetrahydrothiophene 3)Ketone meter).
References:
CN107739366,2018,A Location in patent:Paragraph 0019; 0022; 0023; 0026; 0027; 0030
37784-67-1
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21080-92-2
256 suppliers
$10.00/1g
40548-04-7
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21080-92-2
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