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ChemicalBook CAS DataBase List 3,5-Difluorobenzoic acid
455-40-3

3,5-Difluorobenzoic acid synthesis

11synthesis methods
-

Yield:455-40-3 78%

Reaction Conditions:

with diphenyl diselenide;dihydrogen peroxide in water at 20; for 6 h;Green chemistry;

Steps:

3.2. General Procedure for the Synthesis of Carboxylic Acids 2
General procedure: Diphenyl diselenide (3, 0.006 g; 0.02 mmol) was treated with H2O2 (30%·w/w, 0.1 mL, 1 mmol) andwater (0.2 mL) and stirred at room temperature at 800 rpm until the discoloration of the reaction mixture;then, the aldehyde 1 (1 mmol) was added. After 6 h, the aqueous mixture was extracted three times withEtOAc (3 × 20 mL). The collected organic layers were dried over Na2SO4 and the solvent evaporatedunder reduced pressure.

References:

Sancineto, Luca;Tidei, Caterina;Bagnoli, Luana;Marini, Francesca;Lenardo, Eder J.;Santi, Claudio [Molecules,2015,vol. 20,# 6,p. 10496 - 10510]

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