3,4-DIFLUOROPHENETOLE synthesis
- Product Name:3,4-DIFLUOROPHENETOLE
- CAS Number:163848-46-2
- Molecular formula:C8H8F2O
- Molecular Weight:158.15
Yield:163848-46-2 92.1%
Reaction Conditions:
with tetramethlyammonium chloride;sodium hydroxide in water;N,N-dimethyl-formamide;toluene at 30;Reflux;Industrial scale;
Steps:
4 Preparation of 3,5-difluorophenyl ethyl ether
1000L reactor was charged with sodium hydroxide 40kg, 500kg toluene, 3,4-difluoro-phenol 100kg, Bi administered warmed to reflux trap by trap until no expulsion of water up to give 3,4-difluoro sodium phenoxide. Then cooling to 5kg tetramethylammonium chloride was added after 30 , DMF5kg, plus complete solution of bromoethane 90kg, dropping Albert warmed to reflux incubation reaction to the raw material disappears. After passing cooling to 30 , filtered and the filtrate washed twice 100kg of water was added, layers were separated and the organic layer is a toluene solution of 3,4-difluorophenyl ether. Recovered by distillation of toluene, and then the tower distillation, the product 3,4-difluorophenyl ether 112kg, GC content of> 99.9% and a yield of 92.1%
References:
CN104529723,2016,B Location in patent:Paragraph 0045-0047