2-Aminoethylmethylsulfone hydrochloride synthesis
- Product Name:2-Aminoethylmethylsulfone hydrochloride
- CAS Number:104458-24-4
- Molecular formula:C3H10ClNO2S
- Molecular Weight:159.63
18542-42-2
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$23.19/1g
104458-24-4
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$40.00/2 g
Yield:104458-24-4 94.8%
Reaction Conditions:
with hydrogenchloride;dihydrogen peroxide in water; pH=3 - 4 at 25 - 30;Solvent;
Steps:
1.2 Synthesis of 2-(methylsulfonyl)ethylamine hydrochloride
2000ml three bottles,Was added 2- (methylthio) ethylamine (91 g, 1 mol) and 500 ml of water,With 37% concentrated hydrochloric acid to adjust the pH to 3 ~ 4,Keep the temperature 25 ~ 30 ,Dropping 30% hydrogen peroxide solution (240g, 2.1mol), 1 ~ 1.5h drop finished,The reaction was carried out at 25 to 30 ° C for 10 hours,The solvent was distilled off under reduced pressure,The residue was added to 500 ml of ethanol,Precipitation of white solid,filter,Ethanol wash,60 under reduced pressure to dry 151.2g,Is 2- (methylsulfonyl) ethylamine hydrochloride,Yield 94.8%The purity of the product is 99.8% (GC method).
References:
Shandong Boyuan Pharmaceutical Co., Ltd.;Li Taitong;Wang Qun CN107056661, 2017, A Location in patent:Paragraph 0011; 0029; 0032; 0033; 0035-0037
![Carbamic acid, N-[2-(methylsulfonyl)ethyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/154095-06-4.gif)
154095-06-4
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104458-24-4
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$40.00/2 g
49773-20-8
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104458-24-4
316 suppliers
$40.00/2 g