ChemicalBook CAS DataBase List 2-Amino-3,5-dichloropyridine

2-Amino-3,5-dichloropyridine synthesis

8synthesis methods

Product Name:2-Amino-3,5-dichloropyridine
CAS Number:4214-74-8
Molecular formula:C5H4Cl2N2
Molecular Weight:163

1072-98-6
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$5.00/1g

4214-74-8
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$6.00/5g

Yield:4214-74-8 70.5%

Reaction Conditions:

with N-chloro-succinimide in methanol;N,N-dimethyl-formamide at 45; for 2.5 h;Temperature;Solvent;

Steps:

3

To a 10 L round bottom three-necked flask was added 5500 ml of a 2.5: 1 mixture of DMF and methanol in a volume ratio of 2.500 ml, inserted into a thermometer and equipped with a condensing reflux device, the magnetic stirrer was started and 2560.8 g of 2-amino- Pyridine, N-chlorosuccinimide 6118.4 g, and the reaction was stirred at 45 ° C for 2.5 hours.TLC and GC were determined to complete the reaction.The crude product was distilled off to give the crude product and recrystallized from ethanol to give pure product 2-amino-3,5-dichloropyridine. After drying, the yield was 70.5% and the purity was 98.20% (GC).

References:

CN104016908,2016,B Location in patent:Paragraph 0027; 0028