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ChemicalBook CAS DataBase List 3,5-Dichloropyridine
2457-47-8

3,5-Dichloropyridine synthesis

9synthesis methods
-

Yield:2457-47-8 98 %Chromat.

Reaction Conditions:

with ammonium chloride;zinc in 1,4-dioxane;water at 90 - 92; for 8 h;Product distribution / selectivity;

Steps:

4

2,3,4,5-Tetrachloropyridine (1 g) was charged to a reaction tube containing water (2 ml), 1,4-dioxane (6 ml), ammonium chloride (0.8 g) and zinc powder (1.5 g). Agitation was commenced (magnetic follower) and the reaction tube heated to 90-92° C. for 8 hours. Gas chromatography of the reaction mixture showed that it comprised a monochloropyridine 1.8% and 3,5-dichloropyridine 98%.

References:

US6639079,2003,B1 Location in patent:Page/Page column 4

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