2,4-DIMETHYL-6-HYDROXYPYRIMIDINE synthesis
- Product Name:2,4-DIMETHYL-6-HYDROXYPYRIMIDINE
- CAS Number:6622-92-0
- Molecular formula:C6H8N2O
- Molecular Weight:124.14
Yield:6622-92-0 36%
Reaction Conditions:
with sodium ethanolate in ethanol; for 20 h;Reflux;
Steps:
53.1 2,6-dimethylpyrimidin-4-ol.
2,6-dimethylpyrimidin-4-ol. Ethyl 3-oxobutanoate (10.0 g, 77 mmol) and acetimidamide hydrochloride (7.23 g, 77 mmol) were added to the solution of sodium ethanolate (10.5 g, 154 mmol) in ethanol (200 mL). And the mixture was refluxed for 20 hours. Water (10 mL) was added to the mixture. The resultant mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, dichloromethane /methanol = 15: 1) to give 2,6-dimethylpyrimidin-4-ol as a yellow solid (3.43 g, 36%). LRMS (M + H+) m/z: calcd 124.06; found 124.
References:
WO2013/75083,2013,A1 Location in patent:Paragraph 00374; 00375
