ChemicalBook CAS DataBase List 2-(4-Bromophenyl)naphthalene

2-(4-Bromophenyl)naphthalene synthesis

7synthesis methods

Product Name:2-(4-Bromophenyl)naphthalene
CAS Number:22082-99-1
Molecular formula:C16H11Br
Molecular Weight:283.16

589-87-7 Synthesis

589-87-7
520 suppliers
$10.00/1g

32316-92-0 Synthesis

32316-92-0
468 suppliers
$6.00/1g

22082-99-1
196 suppliers
$8.00/250mg

Yield:22082-99-1 91.11%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;potassium carbonate in 1,4-dioxane;water at 84 - 88; for 9 h;Inert atmosphere;

Steps:

1.1 Step 1. Preparation of 2-(4-bromophenyl)naphthalene

Under the protection of argon, to a 300mL three-necked flask connected with a mechanical stirrer, condenser, and thermometer, add 2-naphthaleneboronic acid (30.0g),P-bromoiodobenzene (49.35g), Pd(PPh3)4 (4.60g), potassium carbonate (24.11g), dioxane (150ml), water (60ml),After refluxing the reaction at 84-88°C for 9h, the temperature was lowered to room temperature, filtered, and the filter cake was washed with water until neutral (pH=7),After adding 250 ml of toluene to the filter cake under reflux and water separation, it passes through a holding column, the column liquid is recrystallized, and dried to obtain 45.0 g of light yellow solid 2-(4-bromophenyl)naphthalene (ie, intermediate 1), yield 91.11%.

References:

CN110963876,2020,A Location in patent:Paragraph 0044-0048

106-37-6 Synthesis