ChemicalBook CAS DataBase List 2,3-Dichlorobenzoyl chloride

2,3-Dichlorobenzoyl chloride synthesis

6synthesis methods

Product Name:2,3-Dichlorobenzoyl chloride
CAS Number:2905-60-4
Molecular formula:C7H3Cl3O
Molecular Weight:209.46

2,3-Dichlorobenzoyl chloride can be prepared by reacting 2,3-dichlorobenzoic acid with thionyl chloride in an inert atmosphere.

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Yield:2905-60-4 88%

Reaction Conditions:

with water;zinc(II) chloride at 160 - 165; for 1 - 7 h;Product distribution / selectivity;

Steps:

2; 4

Example 2: Synthesis of 2,3-dichlorobenzoyl chloride; A reactor was loaded with 168.9 g of 2,3-dichlorobenzotrichloride (assay 98.9 %, 0.63 moles). The product was heated to 100 ⁰C and a catalytic amount of ZnCl₂ (0.2 g) was added. The mixture was further heated to 160 ⁰C. To the reactor was added dropwise 12.0 g of water while keeping temperature at 160 ⁰C. Addition time was 7 hours. The crude product was then let to distil giving 120.5 g of 2,3-dichlorobenzoyl chloride with a GC assay of 99.7 %. Yield was 91.0 %.; Example 4: Synthesis of 2,3-dichlorobenzoyl chloride; A reactor was loaded with 366.5 g of 2,3-dichlorobenzotrichloride (assay 96.0 %, 1.33 moles) and 1 g Of ZnCl₂. The mixture was heated to 160-165 ⁰C. To the reactor was added dropwise24.0 g of water while keeping temperature at 160-165 ⁰C. Addition time was 1 hour. The crude product was then let to distil giving 247.9 g of 2,3-dichlorobenzoyl chloride with a GC assay of 98.9 %. Residue was 23.0 g. Yield was 88.0 %.

References:

WO2007/138075,2007,A1 Location in patent:Page/Page column 13-14

50-45-3 Synthesis