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ChemicalBook >> CAS DataBase List >> WWL113

WWL113

WWL113 price.
  • $37 - $1100
  • Product name: WWL113
  • CAS: 947669-86-5
  • MF: C29H26N2O4
  • MW: 466.52774
  • EINECS:
  • MDL Number:MFCD28160857
  • Synonyms:WWL113;AKIIPHDGVCFVCC-UHFFFAOYSA-N;ethyl 4-[4-[methyl-[(3-pyridin-4-ylphenyl)methyl]carbamoyl]oxyphenyl]benzoate;4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester;WWL-113,WWL113;[1,1'-Biphenyl]-4-carboxylic acid, 4'-[[[methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-, ethyl ester
9 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product numberSYN5248
  • Product descriptionWWL113
  • Packaging50mg
  • Price$560
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5248
  • Product descriptionWWL113
  • Packaging100mg
  • Price$925
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16181
  • Product descriptionWWL113 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16181
  • Product descriptionWWL113 ≥98%
  • Packaging5mg
  • Price$90
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16181
  • Product descriptionWWL113 ≥98%
  • Packaging10mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16181
  • Product descriptionWWL113 ≥98%
  • Packaging25mg
  • Price$353
  • Updated2024-03-01
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number49242
  • Product descriptionWWL113
  • Packaging25mg
  • Price$1100
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberW700000
  • Product descriptionWWL113
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number257115
  • Product descriptionWWL 113
  • Packaging10mg
  • Price$460
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5248 WWL113 50mg $560 2021-12-16 Buy
AK Scientific SYN5248 WWL113 100mg $925 2021-12-16 Buy
Cayman Chemical 16181 WWL113 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 16181 WWL113 ≥98% 5mg $90 2024-03-01 Buy
Cayman Chemical 16181 WWL113 ≥98% 10mg $161 2024-03-01 Buy
Cayman Chemical 16181 WWL113 ≥98% 25mg $353 2024-03-01 Buy
Medical Isotopes, Inc. 49242 WWL113 25mg $1100 2021-12-16 Buy
TRC W700000 WWL113 10mg $180 2021-12-16 Buy
Usbiological 257115 WWL 113 10mg $460 2021-12-16 Buy

Properties

Boiling point :630.9±55.0 °C(Predicted)
Density :1?+-.0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.1 mg/ml
form :A crystalline solid
pka :5.18±0.26(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Mouse carboxylesterase 3 (Ces3, also named Ces 1d) mediates triglyceride hydrolysis in white adipose tissue, liberating free fatty acids into circulation. Although important for basal lipolysis, Ces3 expression can be induced by xenobiotics. Ces3 activity is significantly elevated during adipocyte differentiation. WWL113 is a selective inhibitor of Ces3 and the structurally related Ces 1f (IC50 = ~0.1 μM) without significantly affecting several related enzymes. It significantly reduces basal lipolysis in adipocytes. More interestingly, WWL113 corrects multiple features of metabolic syndrome in obese-diabetic db/db mice, including changes in weight gain, glucose tolerance, and levels of nonesterified free fatty acids, triglycerides, total cholesterol, and fasted glucose. It has similar effects in mice with diet-induced obesity. WWL113 also inhibits the human ortholog of mouse Ces3, hCES1 (IC50 = ~50 nM), which has a similar tissue expression pattern to Ces3.

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