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4′-[[メチル[3-(4-ピリジニル)ベンジル]カルバモイル]オキシ]ビフェニル-4-カルボン酸エチル

4′-[[メチル[3-(4-ピリジニル)ベンジル]カルバモイル]オキシ]ビフェニル-4-カルボン酸エチル price.
2物価
選択條件：
ブランド
  • 富士フイルム和光純薬株式會(huì)社(wako)
パッケージ
  • 10mg
  • 50mg
  • 生産者富士フイルム和光純薬株式會(huì)社(wako)
  • 製品番號(hào)W01TOC5259
  • 製品説明
  • 英語(yǔ)製品説明WWL 113
  • 包裝単位50mg
  • 価格￥235000
  • 更新しました2021-03-23
  • 購(gòu)入
  • 生産者富士フイルム和光純薬株式會(huì)社(wako)
  • 製品番號(hào)W01TOC5259
  • 製品説明
  • 英語(yǔ)製品説明WWL 113
  • 包裝単位10mg
  • 価格￥56000
  • 更新しました2021-03-23
  • 購(gòu)入
生産者 製品番號(hào) 製品説明 包裝単位 価格 更新時(shí)間 購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako) W01TOC5259
WWL 113 		50mg ￥235000 2021-03-23 購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako) W01TOC5259
WWL 113 		10mg ￥56000 2021-03-23 購(gòu)入

プロパティ

沸點(diǎn)  :630.9±55.0 °C(Predicted)
比重(密度)  :1?+-.0.06 g/cm3(Predicted)
貯蔵溫度  :Store at -20°C
溶解性 :DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.1 mg/ml
外見(jiàn)  :A crystalline solid
酸解離定數(shù)(Pka) :5.18±0.26(Predicted)
色 :White to off-white

安全情報(bào)

絵表示(GHS):
注意喚起語(yǔ):
危険有害性情報(bào):
コード 危険有害性情報(bào) 危険有害性クラス 區(qū)分 注意喚起語(yǔ) シンボル P コード
注意書き:

説明

Mouse carboxylesterase 3 (Ces3, also named Ces 1d) mediates triglyceride hydrolysis in white adipose tissue, liberating free fatty acids into circulation. Although important for basal lipolysis, Ces3 expression can be induced by xenobiotics. Ces3 activity is significantly elevated during adipocyte differentiation. WWL113 is a selective inhibitor of Ces3 and the structurally related Ces 1f (IC50 = ~0.1 μM) without significantly affecting several related enzymes. It significantly reduces basal lipolysis in adipocytes. More interestingly, WWL113 corrects multiple features of metabolic syndrome in obese-diabetic db/db mice, including changes in weight gain, glucose tolerance, and levels of nonesterified free fatty acids, triglycerides, total cholesterol, and fasted glucose. It has similar effects in mice with diet-induced obesity. WWL113 also inhibits the human ortholog of mouse Ces3, hCES1 (IC50 = ~50 nM), which has a similar tissue expression pattern to Ces3.

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WWL70 WWL229

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