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ChemicalBook >> CAS DataBase List >> SB216763

SB216763

SB216763 price.
  • $25 - $1802
  • Product name: SB216763
  • CAS: 280744-09-4
  • MF: C19H12Cl2N2O2
  • MW: 371.22
  • EINECS:
  • MDL Number:MFCD09753369
  • Synonyms:SB 216763;3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE;3-(2,4-Dichlorophenyl)-4-...;3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione;SB-216763(SB 216763);GSK-3 Inhibitor IV, SB-216763 ;CS-332;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem
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  • Adipogen Life Sciences
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  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3659-M001
  • Product descriptionSB 216763 ≥98%(HPLC)
  • Packaging1mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100785
  • Product descriptionSB 216763 98%
  • Packaging1mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100785
  • Product descriptionSB 216763 98%
  • Packaging5mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100785
  • Product descriptionSB 216763 98%
  • Packaging10mg
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100785
  • Product descriptionSB 216763 98%
  • Packaging50mg
  • Price$82
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100785
  • Product descriptionSB 216763 98%
  • Packaging100mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100785
  • Product descriptionSB 216763 98%
  • Packaging250mg
  • Price$153
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100785
  • Product descriptionSB 216763 98%
  • Packaging1g
  • Price$368
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100785
  • Product descriptionSB 216763 98%
  • Packaging5g
  • Price$1654
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8240
  • Product descriptionSB 216763
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8240
  • Product descriptionSB 216763
  • Packaging50mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS425004
  • Product descriptionSB 216763 98%
  • Packaging1mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS425004
  • Product descriptionSB 216763 98%
  • Packaging5mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS425004
  • Product descriptionSB 216763 98%
  • Packaging10mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS425004
  • Product descriptionSB 216763 98%
  • Packaging50mg
  • Price$81
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS425004
  • Product descriptionSB 216763 98%
  • Packaging100mg
  • Price$98
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3659-M001 SB 216763 ≥98%(HPLC) 1mg $30 2021-12-16 Buy
Ambeed A100785 SB 216763 98% 1mg $25 2021-12-16 Buy
Ambeed A100785 SB 216763 98% 5mg $42 2021-12-16 Buy
Ambeed A100785 SB 216763 98% 10mg $54 2021-12-16 Buy
Ambeed A100785 SB 216763 98% 50mg $82 2021-12-16 Buy
Ambeed A100785 SB 216763 98% 100mg $99 2021-12-16 Buy
Ambeed A100785 SB 216763 98% 250mg $153 2021-12-16 Buy
Ambeed A100785 SB 216763 98% 1g $368 2021-12-16 Buy
Ambeed A100785 SB 216763 98% 5g $1654 2021-12-16 Buy
ApexBio Technology A8240 SB 216763 10mg $60 2021-12-16 Buy
ApexBio Technology A8240 SB 216763 50mg $200 2021-12-16 Buy
Arctom AS425004 SB 216763 98% 1mg $25 2021-12-16 Buy
Arctom AS425004 SB 216763 98% 5mg $42 2021-12-16 Buy
Arctom AS425004 SB 216763 98% 10mg $53 2021-12-16 Buy
Arctom AS425004 SB 216763 98% 50mg $81 2021-12-16 Buy
Arctom AS425004 SB 216763 98% 100mg $98 2021-12-16 Buy

Properties

Melting point :287-288.6 °C(lit.)
Boiling point :598.1±50.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: 20 mg/mL, soluble
form :Orange solid
pka :7.27±0.60(Predicted)
color :orange
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

SB 216763 is a cell-permeable, potent, selective and ATP-competitive inhibitor of GSK-3 (Glycogen Synthase Kinase) with an IC50 value of 34 nM for GSK-3α and with similar potency for GSK-3β. In PC-12 cells, SB-216763 exhibits neuroprotective properties and protects cultured central and peripheral nervous system neurones from cell death. Furthermore, SB-216763 increases the concentration of cytoplasmic β-catenin through a GSK-3 dependent manner. These inhibitory effects are similar to those of Wnt.

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