SB 203580
- $26 - $2151
- Product name: SB 203580
- CAS: 152121-47-6
- MF: C21H16FN3OS
- MW: 377.43
- EINECS:
- MDL Number:MFCD00922198
- Synonyms:SB 203580 HYDROCHLORIDE;SB 2035850;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL;4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULPHONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE HYDROCHLORIDE;4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine
76 prices
Selected condition:
Brand
- Adipogen Life Sciences
- AK Scientific
- Alfa Aesar
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
Package
- 1
- 1mg
- 10mg
- 20mg
- 1unit
- 5mg
- 10
- 50
- 10mM(in 1mL DMSO)
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0030-M025
- Product descriptionSB 203580 ≥98%
- Packaging25mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1074
- Product descriptionSB 203580
- Packaging5mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ61482
- Product descriptionSB 203580, 98%
- Packaging25mg
- Price$156
- Updated2023-06-20
- Buy
- ManufacturerAlfa Aesar
- Product numberJ61482
- Product descriptionSB 203580, 98%
- Packaging50mg
- Price$224
- Updated2023-06-20
- Buy
- ManufacturerAlfa Aesar
- Product numberJ61482
- Product descriptionSB 203580, 98%
- Packaging100mg
- Price$356
- Updated2023-06-20
- Buy
- ManufacturerAmbeed
- Product numberA248150
- Product descriptionSB 203580 98+%
- Packaging5mg
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248150
- Product descriptionSB 203580 98+%
- Packaging10mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248150
- Product descriptionSB 203580 98+%
- Packaging50mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248150
- Product descriptionSB 203580 98+%
- Packaging100mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248150
- Product descriptionSB 203580 98+%
- Packaging250mg
- Price$289
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA248150
- Product descriptionSB 203580 98+%
- Packaging1g
- Price$706
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000222
- Product descriptionSB 203580 95.00%
- Packaging25MG
- Price$720.12
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000222
- Product descriptionSB 203580 95.00%
- Packaging50MG
- Price$766.69
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000222
- Product descriptionSB 203580 95.00%
- Packaging100MG
- Price$854.01
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8254
- Product descriptionSB 203580
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8254
- Product descriptionSB 203580
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Adipogen Life Sciences | AG-CR1-0030-M025 | SB 203580 ≥98% | 25mg | $300 | 2021-12-16 | Buy |
AK Scientific | SYN1074 | SB 203580 | 5mg | $85 | 2021-12-16 | Buy |
Alfa Aesar | J61482 | SB 203580, 98% | 25mg | $156 | 2023-06-20 | Buy |
Alfa Aesar | J61482 | SB 203580, 98% | 50mg | $224 | 2023-06-20 | Buy |
Alfa Aesar | J61482 | SB 203580, 98% | 100mg | $356 | 2023-06-20 | Buy |
Ambeed | A248150 | SB 203580 98+% | 5mg | $26 | 2021-12-16 | Buy |
Ambeed | A248150 | SB 203580 98+% | 10mg | $41 | 2021-12-16 | Buy |
Ambeed | A248150 | SB 203580 98+% | 50mg | $108 | 2021-12-16 | Buy |
Ambeed | A248150 | SB 203580 98+% | 100mg | $195 | 2021-12-16 | Buy |
Ambeed | A248150 | SB 203580 98+% | 250mg | $289 | 2021-12-16 | Buy |
Ambeed | A248150 | SB 203580 98+% | 1g | $706 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000222 | SB 203580 95.00% | 25MG | $720.12 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000222 | SB 203580 95.00% | 50MG | $766.69 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000222 | SB 203580 95.00% | 100MG | $854.01 | 2021-12-16 | Buy |
ApexBio Technology | A8254 | SB 203580 | 1unit | $28 | 2021-12-16 | Buy |
ApexBio Technology | A8254 | SB 203580 | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
Properties
Melting point :144-146
Boiling point :615.6±55.0 °C(Predicted)
Density :1.4
storage temp. :-20°C
solubility :DMSO: 50 mg/mL
form :solid
pka :9.60±0.10(Predicted)
color :white to off-white
Stability :-200C
InChIKey :CDMGBJANTYXAIV-UHFFFAOYSA-N
CAS DataBase Reference :152121-47-6(CAS DataBase Reference)
Boiling point :615.6±55.0 °C(Predicted)
Density :1.4
storage temp. :-20°C
solubility :DMSO: 50 mg/mL
form :solid
pka :9.60±0.10(Predicted)
color :white to off-white
Stability :-200C
InChIKey :CDMGBJANTYXAIV-UHFFFAOYSA-N
CAS DataBase Reference :152121-47-6(CAS DataBase Reference)
Safety Information
Symbol(GHS): | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Danger | |||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||
Precautionary statements: |
|
Description
Mitogen-activated protein kinases (MAPK) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. SB 203580 is a pyridinyl imidazole inhibitor of p38 MAPK that specifically blocks its kinase activity. SB 203580 does not however, disrupt JNK activity, which is activated by similar stressors to those which activate p38 MAPK. p38 MAPK activity in heat-shocked HeLa cells and osmotically stressed PC12 cells is inhibited by SB 203580 with an IC50 value of 0.6 μM. SB 203580 also prevents the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1) at IC50 values of 3-5 μM.Related product price
- SB 203580 (hydrochloride)
$42-874 - LY 294002 HYDROCHLORIDE
$20-3350 - SCH772984
$37-2400