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ChemicalBook >> CAS DataBase List >> SCH772984

SCH772984

SCH772984 price.
  • $37 - $2400
  • Product name: SCH772984
  • CAS: 942183-80-4
  • MF: C33H33N9O2
  • MW: 587.67
  • EINECS:1592732-453-0
  • MDL Number:MFCD11878503
  • Synonyms:SCH772984;SCH772984/SCH-772984;(3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide;(R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide;(3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide SCH772984;(R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-;SCH772984, >=98%;(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indaz
29 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5640
  • Product descriptionSCH772984
  • Packaging100mg
  • Price$1660
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA378792
  • Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
  • Packaging2mg
  • Price$63
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA378792
  • Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
  • Packaging5mg
  • Price$107
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA378792
  • Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
  • Packaging10mg
  • Price$161
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA378792
  • Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
  • Packaging50mg
  • Price$482
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA378792
  • Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
  • Packaging100mg
  • Price$660
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA378792
  • Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
  • Packaging250mg
  • Price$792
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA378792
  • Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
  • Packaging1g
  • Price$1980
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3805
  • Product descriptionSCH772984
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60064
  • Product descriptionSCH772984
  • Packaging5mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181138
  • Product descriptionSCH-772984 >98%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181138
  • Product descriptionSCH-772984 >98%
  • Packaging100mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS157995
  • Product descriptionSCH 772984
  • Packaging50mg
  • Price$612.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS157995
  • Product descriptionSCH 772984
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19166
  • Product descriptionSCH 772984 ≥95%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19166
  • Product descriptionSCH 772984 ≥95%
  • Packaging5mg
  • Price$161
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5640 SCH772984 100mg $1660 2021-12-16 Buy
Ambeed A378792 (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% 2mg $63 2021-12-16 Buy
Ambeed A378792 (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% 5mg $107 2021-12-16 Buy
Ambeed A378792 (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% 10mg $161 2021-12-16 Buy
Ambeed A378792 (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% 50mg $482 2021-12-16 Buy
Ambeed A378792 (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% 100mg $660 2021-12-16 Buy
Ambeed A378792 (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% 250mg $792 2021-12-16 Buy
Ambeed A378792 (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% 1g $1980 2021-12-16 Buy
ApexBio Technology A3805 SCH772984 10mg $180 2021-12-16 Buy
Arctom CFN60064 SCH772984 5mg $260 2021-12-16 Buy
Biorbyt Ltd orb181138 SCH-772984 >98% 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb181138 SCH-772984 >98% 100mg $765 2021-12-16 Buy
Biosynth Carbosynth FS157995 SCH 772984 50mg $612.5 2021-12-16 Buy
Biosynth Carbosynth FS157995 SCH 772984 10mg $175 2021-12-16 Buy
Cayman Chemical 19166 SCH 772984 ≥95% 1mg $37 2024-03-01 Buy
Cayman Chemical 19166 SCH 772984 ≥95% 5mg $161 2024-03-01 Buy

Properties

Melting point :>214°C (dec.)
Boiling point :857.3±65.0 °C(Predicted)
Density :1.353±0.06(20.0000℃)
storage temp. :Refrigerator
solubility :DMSO (Slightly)
pka :12.05±0.40(Predicted)
form :Solid
color :Pale Yellow
CAS DataBase Reference :942183-80-4

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens. SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively). It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 μM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS. It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.

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