Retigabine
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- $40 - $1871.1
- Product name: Retigabine
- CAS: 150812-12-7
- MF: C16H18FN3O2
- MW: 303.33
- EINECS:629-886-2
- MDL Number:MFCD04307735
- Synonyms:Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate;RetigabineDiscontinued See: R189051;2-AMINO-4-(4-FLUORBENZYLAMINO)-1-ETHOXYCARBONYLAMINOBENZENE; D2312;N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic Acid Ethyl Ester;D 23129;Retigabin;Ezogabine impurity
20 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Biosynth Carbosynth
- Cayman Chemical
- DC Chemicals
- Sigma-Aldrich
- Tocris
Package
- 1mg
- 5mg
- 10MG
- 25mg
- 50mg
- 100MG
- 250mg
- 500mg
- 1mL
- 50
- 1g
- 10mM(in 1mL DMSO)
- 2g
- 5G
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004057
- Product descriptionRETIGABINE 95.00%
- Packaging10MG
- Price$739.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004057
- Product descriptionRETIGABINE 95.00%
- Packaging100MG
- Price$1871.1
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5888
- Product descriptionRetigabine
- Packaging10mM(in 1mL DMSO)
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2632B
- Product descriptionRetigabine
- Packaging10mg
- Price$129
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2632B
- Product descriptionRetigabine
- Packaging100mg
- Price$690
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA61501
- Product description2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene
- Packaging250mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA61501
- Product description2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene
- Packaging500mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA61501
- Product description2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene
- Packaging1g
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA61501
- Product description2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene
- Packaging2g
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA61501
- Product description2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene
- Packaging5G
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21449
- Product descriptionRetigabine
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21449
- Product descriptionRetigabine ≥98%
- Packaging5mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC2089
- Product descriptionRetigabine >98%
- Packaging100mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC2089
- Product descriptionRetigabine >98%
- Packaging250mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC2089
- Product descriptionRetigabine >98%
- Packaging1g
- Price$1000
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0325
- Product descriptionRetigabine ≥98% (HPLC)
- Packaging10mg
- Price$127
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0004057 | RETIGABINE 95.00% | 10MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004057 | RETIGABINE 95.00% | 100MG | $1871.1 | 2021-12-16 | Buy |
| ApexBio Technology | B5888 | Retigabine | 10mM(in 1mL DMSO) | $50 | 2021-12-16 | Buy |
| AvaChem | 2632B | Retigabine | 10mg | $129 | 2021-12-16 | Buy |
| AvaChem | 2632B | Retigabine | 100mg | $690 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA61501 | 2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene | 250mg | $40 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA61501 | 2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene | 500mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA61501 | 2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene | 1g | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA61501 | 2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene | 2g | $190 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA61501 | 2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene | 5G | $450 | 2021-12-16 | Buy |
| Cayman Chemical | 21449 | Retigabine | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 21449 | Retigabine ≥98% | 5mg | $193 | 2024-03-01 | Buy |
| DC Chemicals | DC2089 | Retigabine >98% | 100mg | $250 | 2021-12-16 | Buy |
| DC Chemicals | DC2089 | Retigabine >98% | 250mg | $500 | 2021-12-16 | Buy |
| DC Chemicals | DC2089 | Retigabine >98% | 1g | $1000 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML0325 | Retigabine ≥98% (HPLC) | 10mg | $127 | 2024-03-01 | Buy |
Properties
Boiling point :430.0±45.0 °C(Predicted)
Density :1.307±0.06 g/cm3(Predicted)
Flash point :2℃
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :13.12±0.70(Predicted)
color :white to light brown
BRN :8072099
Stability :Hygroscopic
CAS DataBase Reference :150812-12-7(CAS DataBase Reference)
Density :1.307±0.06 g/cm3(Predicted)
Flash point :2℃
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :13.12±0.70(Predicted)
color :white to light brown
BRN :8072099
Stability :Hygroscopic
CAS DataBase Reference :150812-12-7(CAS DataBase Reference)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||
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Description
Retigabine was approved in March 2011 by the European Commission for the adjunctive treatment of partial-onset seizures in adults who have epilepsy; in June 2011, the U.S. FDA approved the same drug, known in the United States as ezogabine. Retigabine differs from all currently approved antiepileptic drugs in that it acts as a selective positive allosteric modulator (opener) of KCNQ2-5 potassium channels, which are key regulators of neuronal excitability. The discovery of retigabine was based on modification of an analgesic agent flupirtine that had serendipitously shown potent anticonvulsant activity in animal models of epilepsy. Changing a central 2,3,6-triaminopyridine to a 1,2,4-triaminobenzene decreased analgesic activity while enhancing antiepileptic activity. Retigabine (D-23129) was shown to be a broad spectrum anticonvulsant with oral activity in a variety of animal models. The mechanism of action of retigabine was discovered well after its in vivo activity was recognized. Retigabine is regulated as a Schedule V compound in the United States.More related product prices
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