Ponatinib
|
- $22 - $1963.5
- Product name: Ponatinib
- CAS: 943319-70-8
- MF: C29H27F3N6O
- MW: 532.56
- EINECS:1308068-626-2
- MDL Number:MFCD17215203
- Synonyms:AP24534(Ponatinib);3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide;AP24534;AP24534;PONATINIB;3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE;Ponatinib;3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide;Ponatinib (AP24534);Ponatinib (with 4 ints.)
47 prices
Selected condition：
Brand
- Activate Scientific
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
- Usbiological
Package
- 10mM(in 1mL DMSO)
- 1unit
- 1mg
- 5mg
- 20mg
- 10
- 10mg
- 25mg
- 50mg
- 2x25mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1g
- 2g
- ManufacturerActivate Scientific
- Product numberAS10209
- Product descriptionPonatinib 95+%
- Packaging5mg
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS10209
- Product descriptionPonatinib 95+%
- Packaging250mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS10209
- Product descriptionPonatinib 95+%
- Packaging1g
- Price$471
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3538-M001
- Product descriptionPonatinib ≥98%
- Packaging1mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1116-M001
- Product descriptionPonatinib ≥95%
- Packaging1mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1116-M050
- Product descriptionPonatinib ≥95%
- Packaging50mg
- Price$394
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX4747
- Product descriptionPonatinib
- Packaging100mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA485520
- Product description3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+%
- Packaging5mg
- Price$22
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA485520
- Product description3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+%
- Packaging10mg
- Price$29
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA485520
- Product description3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+%
- Packaging25mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA485520
- Product description3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+%
- Packaging50mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA485520
- Product description3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+%
- Packaging100mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA485520
- Product description3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+%
- Packaging250mg
- Price$158
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA485520
- Product description3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+%
- Packaging1g
- Price$394
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000400
- Product descriptionAP-24534 95.00%
- Packaging1MG
- Price$140.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000400
- Product descriptionAP-24534 95.00%
- Packaging10MG
- Price$750.75
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Activate Scientific | AS10209 | Ponatinib 95+% | 5mg | $63 | 2021-12-16 | Buy |
| Activate Scientific | AS10209 | Ponatinib 95+% | 250mg | $225 | 2021-12-16 | Buy |
| Activate Scientific | AS10209 | Ponatinib 95+% | 1g | $471 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3538-M001 | Ponatinib ≥98% | 1mg | $25 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1116-M001 | Ponatinib ≥95% | 1mg | $65 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1116-M050 | Ponatinib ≥95% | 50mg | $394 | 2021-12-16 | Buy |
| AK Scientific | X4747 | Ponatinib | 100mg | $144 | 2021-12-16 | Buy |
| Ambeed | A485520 | 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+% | 5mg | $22 | 2021-12-16 | Buy |
| Ambeed | A485520 | 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+% | 10mg | $29 | 2021-12-16 | Buy |
| Ambeed | A485520 | 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+% | 25mg | $35 | 2021-12-16 | Buy |
| Ambeed | A485520 | 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+% | 50mg | $49 | 2021-12-16 | Buy |
| Ambeed | A485520 | 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+% | 100mg | $79 | 2021-12-16 | Buy |
| Ambeed | A485520 | 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+% | 250mg | $158 | 2021-12-16 | Buy |
| Ambeed | A485520 | 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide 98+% | 1g | $394 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000400 | AP-24534 95.00% | 1MG | $140.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000400 | AP-24534 95.00% | 10MG | $750.75 | 2021-12-16 | Buy |
Properties
Melting point :>175°C (dec.)
Density :1.3
storage temp. :-20°C
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
form :Yellow powder.
pka :12.99±0.70(Predicted)
color :Yellow
Stability :Stable for 2 years from date? of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference :943319-70-8
Density :1.3
storage temp. :-20°C
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
form :Yellow powder.
pka :12.99±0.70(Predicted)
color :Yellow
Stability :Stable for 2 years from date? of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference :943319-70-8
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||
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Description
Ponatinib is an orally available, pan-Bcr-Abl tyrosine kinase inhibitor developed for the treatment of an advanced phase of chronic myeloid leukemia in which mutations of the kinase endow resistance to other Bcr-Abl inhibitors. Ponatinib potently inhibits native Bcr-Abl (IC50 = 0.37 nM) as well as various clinically important mutant forms including Bcr-AblT315I (IC50 = 2 nM). It can also inhibit c-Src (IC50 = 5.4 nM) and VEGFR, FGFR, and PDGFR receptor tyrosine kinases (IC50s = 1-2 nM), yet is >1,000-fold selective against family members of Aurora kinase, insulin receptor kinase, or cyclin-dependent kinase. Ponatinib has been shown to inhibit proliferation of Ba/F3 cells expressing native (IC50 = 0.5 nM) or mutant (IC50s = 0.5-36 nM) Bcr-Abl by inducing apoptosis. In a Ba/F3 Bcr- AblT315I xenograft model, tumor growth was inhibited in mice upon oral dosing at 10-30 mg/kg.Related product price
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