Pifithrin-μ
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- $29 - $1802
- Product name: Pifithrin-μ
- CAS: 64984-31-2
- MF: C8H7NO2S
- MW: 181.21
- EINECS:
- MDL Number:MFCD00181531
- Synonyms:PHENYLETHYNSULFONIC ACID AMIDE;Pifithrin--;Phenyl-ethynesulfonic Acid Amide;Pifithrin-u;2-Phenylethynesulfonamide, PFTμ;EthynesulfonaMide, 2-phenyl-;NSC 303580;Pftmu
34 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10MG
- 25mg
- 50mg
- 100MG
- 50
- 500mg
- 10
- 250mg
- 1g
- 1000mg
- 5g
- ManufacturerAK Scientific
- Product numberX5920
- Product description2-phenylacetylenesulfonamide
- Packaging1g
- Price$619
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0014835
- Product descriptionPHENYLETHYNSULFONIC ACID AMIDE 95.00%
- Packaging100MG
- Price$1732.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0014835
- Product descriptionPHENYLETHYNSULFONIC ACID AMIDE 95.00%
- Packaging10MG
- Price$721.88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4482
- Product descriptionPifithrin-μ
- Packaging50mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181088
- Product descriptionPifithrin-u >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181088
- Product descriptionPifithrin-u >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181088
- Product descriptionPifithrin-u >98%
- Packaging1000mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10748
- Product descriptionPifithrin-μ ≥98%
- Packaging5mg
- Price$54
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10748
- Product descriptionPifithrin-μ ≥98%
- Packaging10mg
- Price$84
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10748
- Product descriptionPifithrin-μ ≥98%
- Packaging25mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10748
- Product descriptionPifithrin-μ ≥98%
- Packaging50mg
- Price$357
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0002901
- Product descriptionPifithrin-μ 98.31%
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD12046988
- Product descriptionPifithrin-μ 95+%
- Packaging100mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD12046988
- Product descriptionPifithrin-μ 95+%
- Packaging50mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD12046988
- Product descriptionPifithrin-μ 95+%
- Packaging25mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD12046988
- Product descriptionPifithrin-μ 95+%
- Packaging10mg
- Price$40
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5920 | 2-phenylacetylenesulfonamide | 1g | $619 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0014835 | PHENYLETHYNSULFONIC ACID AMIDE 95.00% | 100MG | $1732.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0014835 | PHENYLETHYNSULFONIC ACID AMIDE 95.00% | 10MG | $721.88 | 2021-12-16 | Buy |
| ApexBio Technology | A4482 | Pifithrin-μ | 50mg | $190 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181088 | Pifithrin-u >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181088 | Pifithrin-u >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181088 | Pifithrin-u >98% | 1000mg | $1802 | 2021-12-16 | Buy |
| Cayman Chemical | 10748 | Pifithrin-μ ≥98% | 5mg | $54 | 2024-03-01 | Buy |
| Cayman Chemical | 10748 | Pifithrin-μ ≥98% | 10mg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 10748 | Pifithrin-μ ≥98% | 25mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 10748 | Pifithrin-μ ≥98% | 50mg | $357 | 2024-03-01 | Buy |
| ChemScene | CS-0002901 | Pifithrin-μ 98.31% | 10mg | $95 | 2021-12-16 | Buy |
| Crysdot | CD12046988 | Pifithrin-μ 95+% | 100mg | $210 | 2021-12-16 | Buy |
| Crysdot | CD12046988 | Pifithrin-μ 95+% | 50mg | $126 | 2021-12-16 | Buy |
| Crysdot | CD12046988 | Pifithrin-μ 95+% | 25mg | $70 | 2021-12-16 | Buy |
| Crysdot | CD12046988 | Pifithrin-μ 95+% | 10mg | $40 | 2021-12-16 | Buy |
Properties
Melting point :135.0 to 139.0 °C
Boiling point :351.7±25.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble >10mg/mL, clear
pka :7.96±0.60(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :ZZUZYEMRHCMVTB-UHFFFAOYSA-N
Boiling point :351.7±25.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble >10mg/mL, clear
pka :7.96±0.60(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :ZZUZYEMRHCMVTB-UHFFFAOYSA-N
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
In addition to its transactivational functions, p53 mediates apoptosis by binding with the anti-apoptotic proteins Bcl-xL and Bcl-2 at the mitochondrial surface. Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondria without affecting p53 transactivational activities In vitro, PFT-μ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM). PFT-μ reduces p53-mediated apoptosis induced by γ-radiation in mouse thymocytes in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. At 25 μM, PFT-μ reduces apoptosis triggered by nutlin-3, which inhibits MDM2/p53 binding and potentiates p53-mediated growth arrest and apoptosis. PFT-μ also interacts selectively with heat shock protein 70 (HSP70), leading to disruption of the association between HSP70 and many of its co-chaperones and substrate proteins.More related product prices
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