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ChemicalBook >> CAS DataBase List >> Nelarabine

Nelarabine

Nelarabine price.
  • $37 - $1814
  • Product name: Nelarabine
  • CAS: 121032-29-9
  • MF: C11H15N5O5
  • MW: 297.27
  • EINECS:642-916-9
  • MDL Number:MFCD00871078
  • Synonyms:(2R,3S,4S,5R)-2-(2-AMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol;506U78;(2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine;NELARABINE;Nelzarabine [USAN];9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine;Nelarabine (Arranon)
44 prices
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Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 1mg
  • 5mg
  • 10mg
  • 50
  • 25mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberJ10096
  • Product descriptionNelarabine
  • Packaging5mg
  • Price$98.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberR077
  • Product descriptionNelarabine
  • Packaging250mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA161306
  • Product description(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+%
  • Packaging5mg
  • Price$62
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA161306
  • Product description(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+%
  • Packaging10mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA161306
  • Product description(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+%
  • Packaging50mg
  • Price$265
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1379
  • Product descriptionNelarabine
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1379
  • Product descriptionNelarabine
  • Packaging10mM(in 1mL DMSO)
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1379
  • Product descriptionNelarabine
  • Packaging25mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1379
  • Product descriptionNelarabine
  • Packaging100mg
  • Price$880
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS025480
  • Product description(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • Packaging50mg
  • Price$262
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180790
  • Product descriptionNelarabine >99%
  • Packaging100mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180790
  • Product descriptionNelarabine >99%
  • Packaging250mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180790
  • Product descriptionNelarabine >99%
  • Packaging1g
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberNN26176
  • Product descriptionNelarabine
  • Packaging50mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberNN26176
  • Product descriptionNelarabine
  • Packaging100mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberNN26176
  • Product descriptionNelarabine
  • Packaging250mg
  • Price$325
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J10096 Nelarabine 5mg $98.6 2021-12-16 Buy
AK Scientific R077 Nelarabine 250mg $380 2021-12-16 Buy
Ambeed A161306 (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+% 5mg $62 2021-12-16 Buy
Ambeed A161306 (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+% 10mg $104 2021-12-16 Buy
Ambeed A161306 (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+% 50mg $265 2021-12-16 Buy
ApexBio Technology A1379 Nelarabine 5mg $80 2021-12-16 Buy
ApexBio Technology A1379 Nelarabine 10mM(in 1mL DMSO) $90 2021-12-16 Buy
ApexBio Technology A1379 Nelarabine 25mg $280 2021-12-16 Buy
ApexBio Technology A1379 Nelarabine 100mg $880 2021-12-16 Buy
Arctom AS025480 (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 50mg $262 2021-12-16 Buy
Biorbyt Ltd orb180790 Nelarabine >99% 100mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb180790 Nelarabine >99% 250mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb180790 Nelarabine >99% 1g $1802 2021-12-16 Buy
Biosynth Carbosynth NN26176 Nelarabine 50mg $125 2021-12-16 Buy
Biosynth Carbosynth NN26176 Nelarabine 100mg $190 2021-12-16 Buy
Biosynth Carbosynth NN26176 Nelarabine 250mg $325 2021-12-16 Buy

Properties

Melting point :209-217°
alpha :D20 +55.9° (c = 0.27 in DMF)
Boiling point :721.0±70.0 °C(Predicted)
Density :1.98±0.1 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Sonicated)
form :Solid
pka :13.07±0.70(Predicted)
color :White
InChI :InChI=1/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/s3
InChIKey :IXOXBSCIXZEQEQ-GCTRTDOSNA-N
SMILES :N1(C=NC2C(OC)=NC(N)=NC1=2)[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:12,13,15,17,r|
CAS DataBase Reference :121032-29-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Nelarabine is a new member of the purine nucleoside antimetabolite class of drugs. It was launched as an intravenous infusion for treating relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) after at least two prior chemotherapy regimens. Nelarabine is a pro-drug of 9-b-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative with a high level of T-cell selective cytotoxicity. Although Ara-G has been known since the 1960s, it has not been used in clinical studies due to its poor solubility. Nelarabine is the O-methyl derivative of ara-G with approximately 10 times greater aqueous solubility. It is demethylated in vivo by adenosine deaminase to produce ara-G, which is subsequently converted to the active 5’-triphosphate, ara-GTP. Accumulation of ara-GTP in leukemic blasts allows for incorporation into DNA, leading to inhibition of DNA synthesis and cell death.

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