JAK3 Inhibitor
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- $31 - $1500
- Product name: JAK3 Inhibitor
- CAS: 211555-04-3
- MF: C16H14BrN3O3
- MW: 376.2
- EINECS:809-014-9
- MDL Number:MFCD02179366
- Synonyms:JAK3 Inhibitor;2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-;4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154;2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol;JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem;CS-1516;whi-p154cas
28 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberY1400
- Product descriptionWHI-P154
- Packaging5mg
- Price$134
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA134082
- Product descriptionWHI-P154 98+%
- Packaging5mg
- Price$31
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA134082
- Product descriptionWHI-P154 98+%
- Packaging10mg
- Price$43
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA134082
- Product descriptionWHI-P154 98+%
- Packaging50mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA134082
- Product descriptionWHI-P154 98+%
- Packaging100mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA134082
- Product descriptionWHI-P154 98+%
- Packaging250mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA134082
- Product descriptionWHI-P154 98+%
- Packaging1g
- Price$455
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4150
- Product descriptionWHI-P154
- Packaging10mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS445598
- Product descriptionWHI-P154
- Packaging50mg
- Price$233
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBW162805
- Product descriptionWHI-P 154
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBW162805
- Product descriptionWHI-P 154
- Packaging50mg
- Price$409
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16178
- Product descriptionWHI-P154 ≥98%
- Packaging5mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16178
- Product descriptionWHI-P154 ≥98%
- Packaging10mg
- Price$129
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16178
- Product descriptionWHI-P154 ≥98%
- Packaging25mg
- Price$298
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM313065
- Product description2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol 98%
- Packaging50mg
- Price$229
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1605
- Product descriptionWHI-P154 99.20%
- Packaging10mg
- Price$106
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y1400 | WHI-P154 | 5mg | $134 | 2021-12-16 | Buy |
| Ambeed | A134082 | WHI-P154 98+% | 5mg | $31 | 2021-12-16 | Buy |
| Ambeed | A134082 | WHI-P154 98+% | 10mg | $43 | 2021-12-16 | Buy |
| Ambeed | A134082 | WHI-P154 98+% | 50mg | $95 | 2021-12-16 | Buy |
| Ambeed | A134082 | WHI-P154 98+% | 100mg | $122 | 2021-12-16 | Buy |
| Ambeed | A134082 | WHI-P154 98+% | 250mg | $200 | 2021-12-16 | Buy |
| Ambeed | A134082 | WHI-P154 98+% | 1g | $455 | 2021-12-16 | Buy |
| ApexBio Technology | A4150 | WHI-P154 | 10mg | $80 | 2021-12-16 | Buy |
| Arctom | AS445598 | WHI-P154 | 50mg | $233 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BW162805 | WHI-P 154 | 10mg | $95 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BW162805 | WHI-P 154 | 50mg | $409 | 2021-12-16 | Buy |
| Cayman Chemical | 16178 | WHI-P154 ≥98% | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 16178 | WHI-P154 ≥98% | 10mg | $129 | 2024-03-01 | Buy |
| Cayman Chemical | 16178 | WHI-P154 ≥98% | 25mg | $298 | 2024-03-01 | Buy |
| Chemenu | CM313065 | 2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol 98% | 50mg | $229 | 2021-12-16 | Buy |
| ChemScene | CS-1605 | WHI-P154 99.20% | 10mg | $106 | 2021-12-16 | Buy |
Properties
Melting point :230 °C
Boiling point :470.3±45.0 °C(Predicted)
Density :1.576±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble1mg/mL, clear (warmed)
pka :8.57±0.31(Predicted)
form :powder
color :white to brown
InChIKey :CBIAKDAYHRWZCU-UHFFFAOYSA-N
CAS DataBase Reference :211555-04-3
Boiling point :470.3±45.0 °C(Predicted)
Density :1.576±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble1mg/mL, clear (warmed)
pka :8.57±0.31(Predicted)
form :powder
color :white to brown
InChIKey :CBIAKDAYHRWZCU-UHFFFAOYSA-N
CAS DataBase Reference :211555-04-3
Safety Information
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Description
Janus-associated kinase 3 (JAK3) is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription. JAK3 is abundantly expressed in normal lymphoid cells as well as human lymphoblastic and myeloblastic leukemia cells. WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50 = 1.8 μM versus IC50s > 10 μM for JAK1 and JAK2). It has been reported to inhibit additional kinases including EGFR (IC50 = 4 nM) and VEGFR as well as the non-receptor tyrosine kinases, Abl, Lck, and Src. WHI-P154 is cytotoxic to human glioblastoma cells (IC50 = 813 nM) and has been used to induce the differentiation of neuronal precursor cells.Related product price
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