IXABEPILONE
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- $96 - $5803.8
- Product name: IXABEPILONE
- CAS: 219989-84-1
- MF: C27H42N2O5S
- MW: 506.7
- EINECS:630-424-7
- MDL Number:MFCD04307791
- Synonyms:IXABEPILONE;(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E) -1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14. 1.0]heptadecane-8,12-dione;Aza-epothilone B;Bms 247550-1;Ixempra;Ixempra kit;Unii-K27005np0a;Azi-epothilone B
31 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- TRC
Package
- 10mM(in 1mL DMSO)
- 1mg
- 2.5mg
- 5MG
- 10mg
- 25MG
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX7258
- Product descriptionIxabepilone
- Packaging50mg
- Price$1605
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004751
- Product descriptionIXABEPILONE 95.00%
- Packaging5MG
- Price$715
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004751
- Product descriptionIXABEPILONE 95.00%
- Packaging25MG
- Price$2182.95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3513
- Product descriptionIxabepilone
- Packaging10mM(in 1mL DMSO)
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS043974
- Product descriptionIxabepilone ≥98%
- Packaging1mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS043974
- Product descriptionIxabepilone ≥98%
- Packaging5mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS043974
- Product descriptionIxabepilone ≥98%
- Packaging10mg
- Price$334
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS043974
- Product descriptionIxabepilone ≥98%
- Packaging50mg
- Price$1134
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS043974
- Product descriptionIxabepilone ≥98%
- Packaging100mg
- Price$1639
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134815
- Product descriptionIxabepilone >95%
- Packaging100mg
- Price$1654.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134815
- Product descriptionIxabepilone >95%
- Packaging250mg
- Price$2986.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134815
- Product descriptionIxabepilone >95%
- Packaging1g
- Price$5803.8
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD45423
- Product descriptionIxabepilone
- Packaging5mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD45423
- Product descriptionIxabepilone
- Packaging25mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23732
- Product descriptionIxabepilone ≥98%
- Packaging1mg
- Price$96
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23732
- Product descriptionIxabepilone ≥98%
- Packaging5mg
- Price$286
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7258 | Ixabepilone | 50mg | $1605 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004751 | IXABEPILONE 95.00% | 5MG | $715 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004751 | IXABEPILONE 95.00% | 25MG | $2182.95 | 2021-12-16 | Buy |
| ApexBio Technology | A3513 | Ixabepilone | 10mM(in 1mL DMSO) | $245 | 2021-12-16 | Buy |
| Arctom | AS043974 | Ixabepilone ≥98% | 1mg | $98 | 2021-12-16 | Buy |
| Arctom | AS043974 | Ixabepilone ≥98% | 5mg | $190 | 2021-12-16 | Buy |
| Arctom | AS043974 | Ixabepilone ≥98% | 10mg | $334 | 2021-12-16 | Buy |
| Arctom | AS043974 | Ixabepilone ≥98% | 50mg | $1134 | 2021-12-16 | Buy |
| Arctom | AS043974 | Ixabepilone ≥98% | 100mg | $1639 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb134815 | Ixabepilone >95% | 100mg | $1654.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb134815 | Ixabepilone >95% | 250mg | $2986.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb134815 | Ixabepilone >95% | 1g | $5803.8 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD45423 | Ixabepilone | 5mg | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD45423 | Ixabepilone | 25mg | $700 | 2021-12-16 | Buy |
| Cayman Chemical | 23732 | Ixabepilone ≥98% | 1mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 23732 | Ixabepilone ≥98% | 5mg | $286 | 2024-03-01 | Buy |
Properties
Melting point :>160°C (dec.)
alpha :D22 -40.7° (c = 1.0 in chloroform)
Boiling point :697.8±55.0 °C(Predicted)
Density :1.122±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :13.73±0.70(Predicted)
form :White solid.
color :White to Off-White
alpha :D22 -40.7° (c = 1.0 in chloroform)
Boiling point :697.8±55.0 °C(Predicted)
Density :1.122±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :13.73±0.70(Predicted)
form :White solid.
color :White to Off-White
Safety Information
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Description
Ixabepilone, a semisynthetic analog of epothilone B, was launched for the treatment of metastatic or locally advanced breast cancer. It is indicated for use in combination with capecitabine in patients who have previously failed treatment with an anthracycline such as doxorubicin and a taxane such as paclitaxel. It is also approved as monotherapy for the treatment of metastatic or locally advanced breast cancer in patients whose tumors are resistant or refractory to anthracyclines, taxanes, and capecitabine. Ixabepilone is the first member of the epothilone family of anticancer agents to be approved. Epothilones are novel cytotoxic macrolides derived from bacterial fermentation.Like the taxanes, their mechanism of action involves binding to and stabilizing microtubules, which results in mitotic arrest and apoptosis.
The most common adverse reactions (X20%) associated with ixabelipone as monotherapy or in combination with capecitabine were peripheral sensory neuropathy, fatigue/asthenia, myalgia/arthralgia, alopecia, nausea, vomiting, stomatitis/ mucositis, diarrhea, and musculoskeletal pain. The most common hematologic abnormalities (W 40%) include neutropenia, leukopenia, anemia, and thrombocytopenia. Ixabelipone in combination with capecitabine is contraindicated in patients with AST or ALT W2.5 ULN (upper limit of normal) or bilirubin W1 ULN due to increased risk of toxicity and neutropenia-related death.
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