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ChemicalBook >> CAS DataBase List >> Itraconazole

Itraconazole

Itraconazole price.
  • $6 - $1504.5
  • Product name: Itraconazole
  • CAS: 84625-61-6
  • MF: C35H38Cl2N8O4
  • MW: 705.63
  • EINECS:617-596-9
  • MDL Number:MFCD00870168
  • Synonyms:Oriconazole, R51211, Sporanox;4-[4-[4-[4-[[2-(2，4-Dichlomphenyl)-2-(1H-1，2，4-tfiazol-1- yl-methyl)-1,3-dioxolan-4-y1]methoxyl]phenyl]-1-piperazinyl]phenyl]-2，4-dihydro-2-(1-methylpropyl)-3H-1，2，4-triazol-3-one;Oricomzole;Oyiconazole;3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)- 1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-;Canditral;Sporamelt;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(1-methylpropyl)-2,4-dihydro-1,2,4-triazol-3-one
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  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
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  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
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  • Usbiological
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  • ManufacturerAlfa Aesar
  • Product numberJ66390
  • Product descriptionItraconazole, 98%
  • Packaging1g
  • Price$91.8
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ66390
  • Product descriptionItraconazole, 98%
  • Packaging5g
  • Price$180
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ66390
  • Product descriptionItraconazole, 98%
  • Packaging25g
  • Price$795
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA154189
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 98+%
  • Packaging1g
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA154189
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 98+%
  • Packaging10g
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA154189
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 98+%
  • Packaging25g
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA154189
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 98+%
  • Packaging100g
  • Price$320
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006888
  • Product descriptionITRACONAZOLE-D3 95.00%
  • Packaging5MG
  • Price$505.15
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2104
  • Product descriptionItraconazole
  • Packaging1g
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS036635
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98%
  • Packaging100mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS036635
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98%
  • Packaging250mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS036635
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98%
  • Packaging1g
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS036635
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98%
  • Packaging5g
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60376
  • Product descriptionItraconazole ≥98%
  • Packaging20mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS036635
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98%
  • Packaging10g
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS036635
  • Product description4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98%
  • Packaging25g
  • Price$104
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Alfa Aesar J66390 Itraconazole, 98% 1g $91.8 2024-03-01 Buy
Alfa Aesar J66390 Itraconazole, 98% 5g $180 2024-03-01 Buy
Alfa Aesar J66390 Itraconazole, 98% 25g $795 2024-03-01 Buy
Ambeed A154189 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 98+% 1g $10 2021-12-16 Buy
Ambeed A154189 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 98+% 10g $53 2021-12-16 Buy
Ambeed A154189 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 98+% 25g $105 2021-12-16 Buy
Ambeed A154189 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 98+% 100g $320 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006888 ITRACONAZOLE-D3 95.00% 5MG $505.15 2021-12-16 Buy
ApexBio Technology B2104 Itraconazole 1g $250 2021-12-16 Buy
Arctom AS036635 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98% 100mg $6 2021-12-16 Buy
Arctom AS036635 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98% 250mg $8 2021-12-16 Buy
Arctom AS036635 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98% 1g $10 2021-12-16 Buy
Arctom AS036635 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98% 5g $29 2021-12-16 Buy
Arctom CFN60376 Itraconazole ≥98% 20mg $30 2021-12-16 Buy
Arctom AS036635 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98% 10g $52 2021-12-16 Buy
Arctom AS036635 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(sec-butyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ≥98% 25g $104 2021-12-16 Buy

Properties

Melting point :166°C
Boiling point :850.0±75.0 °C(Predicted)
alpha :-0.1～+0.1°(D/20℃)(c=10,CH2Cl2)
Density :1.27 g/cm3
Flash point :>110°(230°F)
storage temp. :2-8°C
solubility :chloroform: 50 mg/mL, clear, colorless
pka :3.7(at 25℃)
form :White powder
color :white
Water Solubility :Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol
Merck :14,5245
Stability :Stable. Incompatible with strong oxidizing agents.
InChIKey :VHVPQPYKVGDNFY-UHFFFAOYSA-N
CAS DataBase Reference :84625-61-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The Hedgehog signaling pathway is critical for embryonic growth and patterning as well as stem cell and progenitor cell tissue homeostasis. Inappropriate Hedgehog activity has been linked to tumor formation. Itraconazole is a systemic antifungal agent with a distinct antagonist effect on Hedgehog signaling. With an IC50 value of 0.8 μM in vitro, itraconazole behaves as an inverse agonist downstream of Patched (Ptch), yet upstream of Smoothened (Smo) to disrupt Hedgehog signaling. Treatment with 100 mg/kg itraconazole twice per day has been shown to suppress the growth of medulloblastomas from a Ptch+/-p53-/- mouse allograft model in as few as five days.

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