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ChemicalBook >> CAS DataBase List >> 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide

4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide

4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide price.
  • $68 - $3282.7
  • Product name: 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide
  • CAS: 908112-43-6
  • MF: C23H27F3N4O3
  • MW: 464.48
  • EINECS:-0
  • MDL Number:MFCD16038907
  • Synonyms:PF 04928473;SNX-2112 (PF-04928473);4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide;4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hyd;4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide;SNX-2112;SNX-2112;4-(6,6-DIMETHYL-4-OXO-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)-2-((1R,4R)-4-HYDROXYCYCLOHEXYLAMINO)BENZAMIDE;2-[(trans-4-Hydroxycyclohexyl)amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]benzamide
22 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX7588
  • Product description4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide
  • Packaging100mg
  • Price$1717
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014149
  • Product descriptionSNX-2112 95.00%
  • Packaging5MG
  • Price$459.8
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4068
  • Product descriptionSNX-2112
  • Packaging5mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4068
  • Product descriptionSNX-2112
  • Packaging10mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4068
  • Product descriptionSNX-2112
  • Packaging10mM(in 1mL DMSO)
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4068
  • Product descriptionSNX-2112
  • Packaging50mg
  • Price$680
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4068
  • Product descriptionSNX-2112
  • Packaging100mg
  • Price$980
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146264
  • Product descriptionSNX-2112 (PF-04928473) >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146264
  • Product descriptionSNX-2112 (PF-04928473) >98%
  • Packaging250mg
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb146264
  • Product descriptionSNX-2112 (PF-04928473) >98%
  • Packaging1g
  • Price$3282.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS103989
  • Product descriptionSNX 2112
  • Packaging10mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS103989
  • Product descriptionSNX 2112
  • Packaging50mg
  • Price$787.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22359
  • Product descriptionSNX-2112 ≥98%
  • Packaging1mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22359
  • Product descriptionSNX-2112 ≥98%
  • Packaging5mg
  • Price$268
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22359
  • Product descriptionSNX-2112 ≥98%
  • Packaging10mg
  • Price$401
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22359
  • Product descriptionSNX-2112 ≥98%
  • Packaging25mg
  • Price$917
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7588 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide 100mg $1717 2021-12-16 Buy
American Custom Chemicals Corporation API0014149 SNX-2112 95.00% 5MG $459.8 2021-12-16 Buy
ApexBio Technology A4068 SNX-2112 5mg $190 2021-12-16 Buy
ApexBio Technology A4068 SNX-2112 10mg $260 2021-12-16 Buy
ApexBio Technology A4068 SNX-2112 10mM(in 1mL DMSO) $280 2021-12-16 Buy
ApexBio Technology A4068 SNX-2112 50mg $680 2021-12-16 Buy
ApexBio Technology A4068 SNX-2112 100mg $980 2021-12-16 Buy
Biorbyt Ltd orb146264 SNX-2112 (PF-04928473) >98% 100mg $838.1 2021-12-16 Buy
Biorbyt Ltd orb146264 SNX-2112 (PF-04928473) >98% 250mg $1504.5 2021-12-16 Buy
Biorbyt Ltd orb146264 SNX-2112 (PF-04928473) >98% 1g $3282.7 2021-12-16 Buy
Biosynth Carbosynth FS103989 SNX 2112 10mg $225 2021-12-16 Buy
Biosynth Carbosynth FS103989 SNX 2112 50mg $787.5 2021-12-16 Buy
Cayman Chemical 22359 SNX-2112 ≥98% 1mg $68 2024-03-01 Buy
Cayman Chemical 22359 SNX-2112 ≥98% 5mg $268 2024-03-01 Buy
Cayman Chemical 22359 SNX-2112 ≥98% 10mg $401 2024-03-01 Buy
Cayman Chemical 22359 SNX-2112 ≥98% 25mg $917 2024-03-01 Buy

Properties

Melting point :265-266℃
Boiling point :619.8±55.0 °C(Predicted)
Density :1.47
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in H2O; ≥9.6 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :15.07±0.50(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

SNX-2112 is a selective heat shock protein 90 (Hsp90) inhibitor which can exert a potent anticancer activity. Studies demonstates that SNX-2112 can exhibit a potent anticancer activity against B16 melanoma cells both in vitro and in vivo, by inhibiting cell proliferation and inducing cell cycle arrest and apoptosis in a mechanism dependent on the degredation of Hsp90 client proteins.