GSK-2256098
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- $34 - $2100
- Product name: GSK-2256098
- CAS: 1224887-10-8
- MF: C20H23ClN6O2
- MW: 414.89
- EINECS:
- MDL Number:MFCD30502650
- Synonyms:GSK-2256098;2-(5-chloro-2-(1-isopropyl-3-methyl-1H-pyrazol-5-ylamino)pyridin-4-ylamino)-N-methoxybenzamide;GTPL7939;Benzamide, 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy-;2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide;CS-2424;FAK inhibitor GS2256098;GSK-2256098;GSK 2256098
22 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 2mg
- 2.5mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- ManufacturerAK Scientific
- Product number3558DG
- Product descriptionGsk2256098
- Packaging1mg
- Price$136
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002595
- Product descriptionGTPL-7939 95.00%
- Packaging5MG
- Price$497.39
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22955
- Product descriptionGSK2256098 ≥98%
- Packaging1mg
- Price$34
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22955
- Product descriptionGSK2256098 ≥98%
- Packaging5mg
- Price$133
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22955
- Product descriptionGSK2256098 ≥98%
- Packaging10mg
- Price$231
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22955
- Product descriptionGSK2256098 ≥98%
- Packaging25mg
- Price$412
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM248327
- Product description2-((5-Chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide 98%
- Packaging250mg
- Price$1571
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6083
- Product descriptionGSK2256098 99.74%
- Packaging2mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6083
- Product descriptionGSK2256098 99.74%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6083
- Product descriptionGSK2256098 99.74%
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6083
- Product descriptionGSK2256098 99.74%
- Packaging25mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6083
- Product descriptionGSK2256098 99.74%
- Packaging50mg
- Price$648
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6083
- Product descriptionGSK2256098 99.74%
- Packaging100mg
- Price$1164
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6083
- Product descriptionGSK2256098 99.74%
- Packaging200mg
- Price$2100
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00012008
- Product descriptionGSK2256098 98+%
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00012008
- Product descriptionGSK2256098 98+%
- Packaging10mg
- Price$147
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3558DG | Gsk2256098 | 1mg | $136 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002595 | GTPL-7939 95.00% | 5MG | $497.39 | 2021-12-16 | Buy |
| Cayman Chemical | 22955 | GSK2256098 ≥98% | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 22955 | GSK2256098 ≥98% | 5mg | $133 | 2024-03-01 | Buy |
| Cayman Chemical | 22955 | GSK2256098 ≥98% | 10mg | $231 | 2024-03-01 | Buy |
| Cayman Chemical | 22955 | GSK2256098 ≥98% | 25mg | $412 | 2024-03-01 | Buy |
| Chemenu | CM248327 | 2-((5-Chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide 98% | 250mg | $1571 | 2021-12-16 | Buy |
| ChemScene | CS-6083 | GSK2256098 99.74% | 2mg | $72 | 2021-12-16 | Buy |
| ChemScene | CS-6083 | GSK2256098 99.74% | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-6083 | GSK2256098 99.74% | 10mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-6083 | GSK2256098 99.74% | 25mg | $360 | 2021-12-16 | Buy |
| ChemScene | CS-6083 | GSK2256098 99.74% | 50mg | $648 | 2021-12-16 | Buy |
| ChemScene | CS-6083 | GSK2256098 99.74% | 100mg | $1164 | 2021-12-16 | Buy |
| ChemScene | CS-6083 | GSK2256098 99.74% | 200mg | $2100 | 2021-12-16 | Buy |
| Crysdot | CD00012008 | GSK2256098 98+% | 5mg | $105 | 2021-12-16 | Buy |
| Crysdot | CD00012008 | GSK2256098 98+% | 10mg | $147 | 2021-12-16 | Buy |
Properties
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:47.33(Max Conc. mg/mL);114.08(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);72.31(Max Conc. mM)
Ethanol:56.0(Max Conc. mg/mL);134.98(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.48(Max Conc. mM) form :A crystalline solid
pka :5.24±0.10(Predicted)
color :White to khaki
InChI :InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)
InChIKey :BVAHPPKGOOJSPU-UHFFFAOYSA-N
SMILES :C(NOC)(=O)C1=CC=CC=C1NC1C(Cl)=CN=C(NC2N(C(C)C)N=C(C)C=2)C=1
storage temp. :Store at -20°C
solubility :DMSO:47.33(Max Conc. mg/mL);114.08(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);72.31(Max Conc. mM)
Ethanol:56.0(Max Conc. mg/mL);134.98(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.48(Max Conc. mM) form :A crystalline solid
pka :5.24±0.10(Predicted)
color :White to khaki
InChI :InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)
InChIKey :BVAHPPKGOOJSPU-UHFFFAOYSA-N
SMILES :C(NOC)(=O)C1=CC=CC=C1NC1C(Cl)=CN=C(NC2N(C(C)C)N=C(C)C=2)C=1
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
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Description
GSK2256098 is an inhibitor of focal adhesion kinase (FAK). It is selective for FAK, inhibiting only FAK greater than 50% in a panel of 261 kinases. GSK2256098 inhibits FAK autophosphorylation at tyrosine 397 (Y397) in OVCAR8 ovarian, U87MG glioblastoma, and A549 lung cancer cell lines (IC50s = 15, 8.5, and 12 nM, respectively). It induces apoptosis and increases PARP levels, decreases viability (IC50 = 25 μM), and inhibits colony formation in L3.6P1 cells. GSK2256098 (75 mg/kg per day) also leads to lower tumor weight and fewer metastases in the Ishikawa orthotopic mouse model of uterine cancer.More related product prices
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