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ChemicalBook >> CAS DataBase List >> N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide

N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide

N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide price.
  • $34 - $5935
  • Product name: N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide
  • CAS: 864082-47-3
  • MF: C21H16F4N4O2
  • MW: 432.37
  • EINECS:
  • MDL Number:MFCD16618404
  • Synonyms:RHO-15(GSK429286A);GSK 429286 A;RHO-15;N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide;GSK 429286 A N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide;N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide GSK 429286 A;N-(6-Fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyridinecarboxamide;N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide
32 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
Package
  • 10mg
  • 25mg
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • 5g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1071-M005
  • Product descriptionGSK429286A ≥95%
  • Packaging5mg
  • Price$167
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1071
  • Product descriptionGSK429286A
  • Packaging1mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1071
  • Product descriptionGSK429286A
  • Packaging50mg
  • Price$685
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA569516
  • Product descriptionGSK429286A 98+%
  • Packaging1mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA569516
  • Product descriptionGSK429286A 98+%
  • Packaging5mg
  • Price$178
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA569516
  • Product descriptionGSK429286A 98+%
  • Packaging10mg
  • Price$231
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA569516
  • Product descriptionGSK429286A 98+%
  • Packaging25mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA569516
  • Product descriptionGSK429286A 98+%
  • Packaging50mg
  • Price$389
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA569516
  • Product descriptionGSK429286A 98+%
  • Packaging100mg
  • Price$505
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5611
  • Product descriptionGSK429286A
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5611
  • Product descriptionGSK429286A
  • Packaging10mM(in 1mL DMSO)
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5611
  • Product descriptionGSK429286A
  • Packaging25mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5611
  • Product descriptionGSK429286A
  • Packaging100mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60381
  • Product descriptionGSK429286A
  • Packaging5mg
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180862
  • Product descriptionGSK-429286A >98%
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180862
  • Product descriptionGSK-429286A >98%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1071-M005 GSK429286A ≥95% 5mg $167 2021-12-16 Buy
AK Scientific SYN1071 GSK429286A 1mg $110 2021-12-16 Buy
AK Scientific SYN1071 GSK429286A 50mg $685 2021-12-16 Buy
Ambeed A569516 GSK429286A 98+% 1mg $59 2021-12-16 Buy
Ambeed A569516 GSK429286A 98+% 5mg $178 2021-12-16 Buy
Ambeed A569516 GSK429286A 98+% 10mg $231 2021-12-16 Buy
Ambeed A569516 GSK429286A 98+% 25mg $300 2021-12-16 Buy
Ambeed A569516 GSK429286A 98+% 50mg $389 2021-12-16 Buy
Ambeed A569516 GSK429286A 98+% 100mg $505 2021-12-16 Buy
ApexBio Technology A5611 GSK429286A 5mg $80 2021-12-16 Buy
ApexBio Technology A5611 GSK429286A 10mM(in 1mL DMSO) $88 2021-12-16 Buy
ApexBio Technology A5611 GSK429286A 25mg $240 2021-12-16 Buy
ApexBio Technology A5611 GSK429286A 100mg $600 2021-12-16 Buy
Arctom CFN60381 GSK429286A 5mg $188 2021-12-16 Buy
Biorbyt Ltd orb180862 GSK-429286A >98% 100mg $690.2 2021-12-16 Buy
Biorbyt Ltd orb180862 GSK-429286A >98% 250mg $1356.6 2021-12-16 Buy

Properties

Boiling point :688.4±55.0 °C(Predicted)
Density :1.468
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥10mg/mL
pka :12.10±0.40(Predicted)
form :powder
color :white to beige
CAS DataBase Reference :864082-47-3

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

GSK429286A is a cell-permeable inhibitor of Rho-associated kinase (IC50 = 14 nM). It less potently inhibits p90 and p70 ribosomal S6 kinases (IC50s = 780 and 1,940 nM, respectively) and is ineffective against leucine-rich repeat protein kinase-2. GSK429286A reverses adrenalin-induced contraction of rat aortic rings (IC50 = 190 nM) and produces a dose-dependent decrease in mean arterial pressure in spontaneously-hypertensive rats.

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