8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
![8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione price.](/CAS/GIF/155270-99-8.gif)
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- $50 - $3193.05
- Product name: 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione
- CAS: 155270-99-8
- MF: C20H24N4O4
- MW: 384.43
- EINECS:
- MDL Number:MFCD00928421
- Synonyms:8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione;istradefylline;KW-6002;10mg 50mg 100mg 1g 5g;(E)-8-(3,4-diMethoxystyryl)-1,3-diethyl-7-Methyl-1H-purine-2,6(3H,7H)-dione;8-[(E)-2-(3,4-diMethoxyphenyl)ethenyl]-1,3-diethyl-7-Methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione;Istradefylline (KW-6002);1H-Purine-2,6-dione,8-[(1E)-2-(3,4-diMethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-Methyl-
37 prices
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Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 50
- 5mg
- 250mg
- 500mg
- 1G
- 10
- 10mg
- 25MG
- 50mg
- 100mg
- 200mg
- 2g
- 5G
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBIO0000203
- Product descriptionKW-6002 95.00%
- Packaging1G
- Price$3193.05
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBIO0000203
- Product descriptionKW-6002 95.00%
- Packaging25MG
- Price$1313.57
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8454
- Product descriptionIstradefylline(KW-6002)
- Packaging10mg
- Price$66
- Updated2021-12-16
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- ManufacturerApexBio Technology
- Product numberA8454
- Product descriptionIstradefylline(KW-6002)
- Packaging50mg
- Price$155
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134385
- Product descriptionIstradefylline (KW-6002) >99%
- Packaging100mg
- Price$510
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFI32579
- Product descriptionIstradefylline
- Packaging5G
- Price$300
- Updated2021-12-16
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- ManufacturerBiosynth Carbosynth
- Product numberFI32579
- Product descriptionIstradefylline
- Packaging2g
- Price$140
- Updated2021-12-16
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- ManufacturerBiosynth Carbosynth
- Product numberFI32579
- Product descriptionIstradefylline
- Packaging1g
- Price$95
- Updated2021-12-16
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- ManufacturerBiosynth Carbosynth
- Product numberFI32579
- Product descriptionIstradefylline
- Packaging500mg
- Price$70
- Updated2021-12-16
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- ManufacturerBiosynth Carbosynth
- Product numberFI32579
- Product descriptionIstradefylline
- Packaging250mg
- Price$50
- Updated2021-12-16
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- ManufacturerCayman Chemical
- Product number22958
- Product descriptionIstradefylline ≥98%
- Packaging5mg
- Price$121
- Updated2024-03-01
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- ManufacturerCayman Chemical
- Product number22958
- Product descriptionIstradefylline ≥98%
- Packaging10mg
- Price$183
- Updated2024-03-01
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- ManufacturerCayman Chemical
- Product number22958
- Product descriptionIstradefylline ≥98%
- Packaging25mg
- Price$423
- Updated2024-03-01
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- ManufacturerChemenu
- Product numberCM138686
- Product description8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione 98%
- Packaging50mg
- Price$492
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM138686
- Product description8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione 98%
- Packaging10mg
- Price$128
- Updated2021-12-16
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- ManufacturerChem-Impex
- Product number37981
- Product descriptionIstradefylline,≥98%(HPLC) ≥98%(HPLC)
- Packaging250MG
- Price$121.14
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | BIO0000203 | KW-6002 95.00% | 1G | $3193.05 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BIO0000203 | KW-6002 95.00% | 25MG | $1313.57 | 2021-12-16 | Buy |
| ApexBio Technology | A8454 | Istradefylline(KW-6002) | 10mg | $66 | 2021-12-16 | Buy |
| ApexBio Technology | A8454 | Istradefylline(KW-6002) | 50mg | $155 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb134385 | Istradefylline (KW-6002) >99% | 100mg | $510 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI32579 | Istradefylline | 5G | $300 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI32579 | Istradefylline | 2g | $140 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI32579 | Istradefylline | 1g | $95 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI32579 | Istradefylline | 500mg | $70 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FI32579 | Istradefylline | 250mg | $50 | 2021-12-16 | Buy |
| Cayman Chemical | 22958 | Istradefylline ≥98% | 5mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 22958 | Istradefylline ≥98% | 10mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 22958 | Istradefylline ≥98% | 25mg | $423 | 2024-03-01 | Buy |
| Chemenu | CM138686 | 8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione 98% | 50mg | $492 | 2021-12-16 | Buy |
| Chemenu | CM138686 | 8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione 98% | 10mg | $128 | 2021-12-16 | Buy |
| Chem-Impex | 37981 | Istradefylline,≥98%(HPLC) ≥98%(HPLC) | 250MG | $121.14 | 2021-12-16 | Buy |
Properties
Melting point :191 °C
Boiling point :601.0±65.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (clear solution)
form :powder
pka :0.47±0.70(Predicted)
color :white to beige
InChIKey :IQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS DataBase Reference :155270-99-8
Boiling point :601.0±65.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (clear solution)
form :powder
pka :0.47±0.70(Predicted)
color :white to beige
InChIKey :IQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS DataBase Reference :155270-99-8
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
In March 2013, istradefylline (also known as KW-6002) was approved in Japan for adjunctive treatment of Parkinson’s disease (PD). Istradefylline acts by antagonism of the adenosine A2A receptor, which is colocalized with dopamine D2 receptors in the striatum, to enhance dopamine D2-dependent signaling. Istradefylline is a light-sensitive compound and has been evaluated in vitro under low-light conditions to prevent isomerization of the (E)-styryl group and decomposition. Istradefylline has a Ki of 2.2 nM for the rat adenosine A2A receptor and an ED50 of 0.03 mg/kg, po, in reversal of haloperidol-induced catalepsy in mice. Further characterization showed istradefylline to have a Ki of 12 nM for the human adenosine A2A receptor, to be highly selective, and to be a functional competitive antagonist. Istradefylline has activity alone and in combination with levo-dopa in preclinical animal models of PD. The synthesis of istradefylline was accomplished by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-mediated coupling of 5,6-diamino-1,3-diethyluracil with 3,4-dimethoxycinnamic acid, followed by cyclization upon treatment with aqueous NaOH, and selective methylation (MeI, K2CO3, and DMF).Related product price
- 4-DesMethyl Istradefylline
$496-1540 - Itraconazole
$6-1504.5 - 1,3-DIETHYL-5,6-DIAMINOURACIL
$199-1175
Suppliers and manufacturers
Firsky International Trade (Wuhan) Co., Ltd
![8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione](/ProductImageEN/2023-10/small/79279382-8a53-4cde-83b5-9875dd370255.jpg)
$30.00/KG
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8
Wuhan Ruichi Technology Co., Ltd
![8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione](/ProductImageEN/2024-01/small/6f373825-6b89-45f3-a1e8-0e2a4b52ce77.jpg)
$30.00 /1KG
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8
career henan chemical co
![8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione](https://img.chemicalbook.com/ProductImageEN/2018-7/small/4dfaaeee-b5e0-44de-9227-69d027cd7010.jpg)
Shanghai Daken Advanced Materials Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei xin bonus chemical co. LTD
$85.00 /1KG
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione CAS:155270-99-8