[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
- $26 - $650
- Product name: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
- CAS: 1469284-79-4
- MF: C23H30ClN7O4S
- MW: 536.0468
- EINECS:
- MDL Number:MFCD28137684
- Synonyms:[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate;PF-06424439 >=98% (HPLC);PF-06424439 methanesulfonate;PF-06424439;acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439;(R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate
16 prices
Selected condition:
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number2389EB
- Product descriptionPF-06424439(methanesulfonate)
- Packaging1mg
- Price$166
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17680
- Product descriptionPF-06424439 ≥98%
- Packaging500μg
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17680
- Product descriptionPF-06424439 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17680
- Product descriptionPF-06424439 ≥98%
- Packaging5mg
- Price$87
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17680
- Product descriptionPF-06424439 ≥98%
- Packaging10mg
- Price$151
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17680
- Product descriptionPF-06424439 ≥98%
- Packaging25mg
- Price$321
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0068288
- Product descriptionPF-06424439methanesulfonate 99.94%
- Packaging1mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0068288
- Product descriptionPF-06424439methanesulfonate 99.94%
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0068288
- Product descriptionPF-06424439methanesulfonate 99.94%
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0068288
- Product descriptionPF-06424439methanesulfonate 99.94%
- Packaging25mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0068288
- Product descriptionPF-06424439methanesulfonate 99.94%
- Packaging50mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0068288
- Product descriptionPF-06424439methanesulfonate 99.94%
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberPZ0233
- Product descriptionPF-06424439 ≥98% (HPLC)
- Packaging5mg
- Price$118
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberPZ0233
- Product descriptionPF-06424439 ≥98% (HPLC)
- Packaging25mg
- Price$476
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number6348
- Product descriptionPF06424439 ≥98%(HPLC)
- Packaging5
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberP294143
- Product descriptionPF06424439
- Packaging25mg
- Price$370
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 2389EB | PF-06424439(methanesulfonate) | 1mg | $166 | 2021-12-16 | Buy |
Cayman Chemical | 17680 | PF-06424439 ≥98% | 500μg | $26 | 2021-12-16 | Buy |
Cayman Chemical | 17680 | PF-06424439 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 17680 | PF-06424439 ≥98% | 5mg | $87 | 2024-03-01 | Buy |
Cayman Chemical | 17680 | PF-06424439 ≥98% | 10mg | $151 | 2024-03-01 | Buy |
Cayman Chemical | 17680 | PF-06424439 ≥98% | 25mg | $321 | 2024-03-01 | Buy |
ChemScene | CS-0068288 | PF-06424439methanesulfonate 99.94% | 1mg | $50 | 2021-12-16 | Buy |
ChemScene | CS-0068288 | PF-06424439methanesulfonate 99.94% | 5mg | $70 | 2021-12-16 | Buy |
ChemScene | CS-0068288 | PF-06424439methanesulfonate 99.94% | 10mg | $120 | 2021-12-16 | Buy |
ChemScene | CS-0068288 | PF-06424439methanesulfonate 99.94% | 25mg | $250 | 2021-12-16 | Buy |
ChemScene | CS-0068288 | PF-06424439methanesulfonate 99.94% | 50mg | $400 | 2021-12-16 | Buy |
ChemScene | CS-0068288 | PF-06424439methanesulfonate 99.94% | 100mg | $650 | 2021-12-16 | Buy |
Sigma-Aldrich | PZ0233 | PF-06424439 ≥98% (HPLC) | 5mg | $118 | 2024-03-01 | Buy |
Sigma-Aldrich | PZ0233 | PF-06424439 ≥98% (HPLC) | 25mg | $476 | 2024-03-01 | Buy |
Tocris | 6348 | PF06424439 ≥98%(HPLC) | 5 | $75 | 2021-12-16 | Buy |
TRC | P294143 | PF06424439 | 25mg | $370 | 2021-12-16 | Buy |
Properties
storage temp. :room temp
solubility :H2O: soluble10mg/mL, clear
form :powder
color :white to light brown
solubility :H2O: soluble10mg/mL, clear
form :powder
color :white to light brown
Safety Information
Symbol(GHS): | ||||||||
---|---|---|---|---|---|---|---|---|
Signal word: | ||||||||
Hazard statements: |
|
|||||||
Precautionary statements: |
|
Description
PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2; IC50 = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 μM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner. It also reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet when administered at a dose of 60 mg/kg per day.More related product prices
PF 477736 PF-04691502 PF-05212384 PF-5190457 PF 573228 PF-3084014 PF 04995274 PF 3644022 PF-06447475 PF-05089771 (tosylate) PF-06650833 PF-06700841 tosylateRelated product price
- PF 477736
$41-2440 - PF-04691502
$70-3728.1 - PF-05212384
$37-2575
Suppliers and manufacturers
Nantong HI-FUTURE Biology Co., Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Guangzhou Isun Pharmaceutical Co., Ltd
ShangHai Caerulum Pharma Discovery Co., Ltd.
Sigma-Aldrich
Shanghai EFE Biological Technology Co., Ltd.