| Identification | Back Directory | [Name]
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate | [CAS]
1469284-79-4 | [Synonyms]
PF-06424439
PF-06424439 >=98% (HPLC)
PF-06424439 methanesulfonate
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate | [Molecular Formula]
C23H30ClN7O4S | [MDL Number]
MFCD28137684 | [MOL File]
1469284-79-4.mol | [Molecular Weight]
536.047 |
| Hazard Information | Back Directory | [Description]
PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2; IC50 = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 μM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner. It also reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet when administered at a dose of 60 mg/kg per day. | [Uses]
PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2)?inhibitor:
- to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
- to study its effects on HeLa cells
- to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells
| [Biochem/physiol Actions]
PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2). | [storage]
Store at -20°C |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
BOC Sciences
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https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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