PF-06424439 methanesulfonate NEW
| Price | $39 | $55 | $97 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: PF-06424439 methanesulfonate | CAS No.: 1469284-79-4 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | PF-06424439 methanesulfonate |
| 描述 | PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2. |
| 動物實驗 | PF-06424439 methanesulfonate (i.v.; 1 mg/kg) shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].PF-06424439 methanesulfonate (p.o.; 60 mg/kg/day; for 3 days) reduces plasma TG and cholesterol levels and decreases nonsignificant in circulating lipids in mice (Ldlr-/-)[1]. |
| 體內(nèi)活性 | PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 249 mg/mL (464.50 mM), Sonication is recommended. H2O : 99 mg/mL (184.68 mM) |
| 關鍵字 | acyl-CoA:cholesterol acyltransferase | Inhibitor | Acyltransferase | mono- acylglycerol acyltransferase | PF-06424439 | PF 06424439 methanesulfonate | inhibit | Diacylglycerol acyltransferase | PF06424439 | Diglyceride acyltransferase | PF06424439 methanesulfonate | PF 06424439 | PF-06424439 methanesulfonate |
| 相關產(chǎn)品 | Serotonin hydrochloride | Risedronate Sodium | Cyclandelate | Risedronic Acid | YM17E | 3-Methoxybenzamide | Entacapone | 2-Furoic acid | OU749 | Ibandronate sodium | Alendronate sodium hydrate | Flopropione |
| 相關庫 | 經(jīng)典已知活性庫 | 抗肥胖化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 脂代謝化合物庫 | 代謝化合物庫 | 口服活性化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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