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ChemicalBook >> CAS DataBase List >> Abacavir Related CoMpound D

Abacavir Related CoMpound D

Abacavir Related CoMpound D price.
  • $130 - $1360
  • Product name: Abacavir Related CoMpound D
  • CAS: 1443421-69-9
  • MF: C18H21ClN10O
  • MW: 428.88
  • EINECS:
  • MDL Number:MFCD28137825
  • Synonyms:Abacavir Related CoMpound D;N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine;Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine;Abacavir EP Impurity B;O-Pyrimidine Derivative Abacavir (USP);6-(Cyclopropylamino)-9-[(1R,4S)-4-[[(2,5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine;9H-Purine-2,6-diamine, N6-cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4-pyrimidinyl)oxy]methyl]-2-cyclopenten-1-yl]-;Abacavir Impurity D
4 prices
Selected condition:
Brand
  • American Custom Chemicals Corporation
  • Sigma-Aldrich
  • TRC
Package
  • 2.5mg
  • 5MG
  • 20mg
  • 25mg
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0027217
  • Product descriptionABACAVIR O-PYRIMIDINE IMPURITY 95.00%
  • Packaging5MG
  • Price$504.96
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number1000437
  • Product descriptionAbacavir Related Compound D
  • Packaging20mg
  • Price$1360
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberA105035
  • Product descriptionAbacavir5’-4-Chloro-6-methylpyrimidine-2,5-diamine
  • Packaging2.5mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberA105035
  • Product descriptionAbacavir5’-4-Chloro-6-methylpyrimidine-2,5-diamine
  • Packaging25mg
  • Price$1050
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation API0027217 ABACAVIR O-PYRIMIDINE IMPURITY 95.00% 5MG $504.96 2021-12-16 Buy
Sigma-Aldrich 1000437 Abacavir Related Compound D 20mg $1360 2024-03-01 Buy
TRC A105035 Abacavir5’-4-Chloro-6-methylpyrimidine-2,5-diamine 2.5mg $130 2021-12-16 Buy
TRC A105035 Abacavir5’-4-Chloro-6-methylpyrimidine-2,5-diamine 25mg $1050 2021-12-16 Buy

Properties

Boiling point :830.1±75.0 °C(Predicted)
Density :1.90±0.1 g/cm3(Predicted)
pka :4.86±0.10(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.